СПИСОК ЛИТЕРАТУРЫ

1. Клиническая ревматология (руководство для врачей) / И.Б. Беляева, Е.Г. Зоткин, Н.А. Куницкая и др. [под ред. В.И. Мазурова]. - СПб., 2005. - 514 с.

2. Насонов, Е.Л. Иммунопатология ревматоидного артрита и остеопороз: новые данные / Е.Л.

3. Насонов, Е.Л. Новые аспекты применения циклоспорина А (Сандиммун) в ревматологии: лечение системной красной волчанки / Е.Л. Насонов, Н.Г. Клюквина, С.В. Шекшина, В.А. Насонова // Терапевтический архив. - 2000. - № 5. - С. 67-71.

4. Насонов, Е.Л. Противовоспалительная терапия ревматических болезней / Е.Л. Насонов. - М., 1996. - 520 с.

5. Павлов, А.Д. Эритропоэз, эритропоэтин, железо. Молекулярные и клинические аспекты / А.Д. Павлов, Е.Ф. Морщакова, А.Г. Румянцев. - М., 2011. - 304 с.

6. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative / D. Aletaha, T. Neogi, A.J. Silman et al. / Arthritis Rheum. - 2010. - №62(9). - Р. 2569-2581.

7. A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression / D.L. Zhang, R.M. Hughes, H. Ollivierre-Wilson et al. // Cell Metab. - 2009. - № 9. - Р. 461-473.

8. A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine­receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling / P. Minoo, M.M. Zadeh, R. Rottapel et al. // Blood. - 2004. - №103. - Р. 1398-1407.

9. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression / R.H. Wang, C. Li, X. Xu et al. // Cell Metab. - 2005. - №2. - Р. 399-409.

10. Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus / O.

11. Adams, A. Update on the pathogenesis and treatment of systemic onset juvenile rheumatoid arthritis / A. Adams, T.J. Lehman // Curr Opin Rheumatol. - 2005. - №17. - P. 612-616.

12. Andrews, N.C. Anemia of inflammation: the cytokine-hepcidin link / N.C. Andrews // J Clin Invest. - 2004. - №113(9). - Р. 1251-1253.

13. Andrews, N.C. The iron transporter DMT1 / N.C. Andrews // Int J Biochem Cell Biol. - 1999. - №31. - Р. 991-994.

14. Anemia and blood transfusion in critically ill patients / J.L. Vincent, J.F. Baron,

K. Reinhart et al. // JAMA. - 2002. - №288. - Р. 1499-1507.

15. Anti-citrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione S-transferase in a cross-sectional study / T.R. Mikuls, K.A. Gould,

K.K. Bynote, et al. // Arthritis Res Ther. - 2010. - №12. - Р. R213.

16. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFa, anti-IL-1a/e, and IL-1Ra / L.A.B. Joosten, M.M.A. Helsen, F.A.J. van de Loo, W.B. van den Berg // Arthritis Rheum. - 1996. - №39. - Р. 797-809.

17. Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis / L.S. Ou, L.C. See, C.J. Wu et al. // Clin Rheumatol. - 2002. - №21. - Р. 52-56.

18. Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene / A. Hinks, A. Barton, S. John et al. // Arthritis Rheum. -

2005. - №52. - Р. 1694-1699.

19. Association of anemia and physical disability among patients with rheumatoid arthritis / C. Han, M.U. Rahman, M.K. Doyle et al. // J Rheumatol. - 2007. - №34(11). - Р. 2177-2182.

20. Association of antigen specificity and migratory capacity of memory T cells in rheumatoid arthritis / K.R.

21. Association of HLA-B27 genetic polymorphisms with ankylosing spondylitis susceptibility worldwide: a meta-analysis / T. Yang, Z. Duan, S. Wu et al. // Mod Rheumatol. - 2014. - №24(1). - Р. 150-161.

22. Autologous stem cell transplantation for autoimmunity induces immunologic self­tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network / I. De Kleer, B. Vastert, M. Klein et al. // Blood. -

2006. - №107. - Р. 1696-1702.

23. Barosi, G. Inadequate erythropoietin response to anemia: definition and clinical relevance / G. Barosi // Ann Hematol. - 1994. - №68. - Р.215-223.

24. Bijlsma, J.W. Methotrexate: still the anchor drug in RA treatment / J.W. Bijlsma,

J.W. Jacobs // Joint Bone Spine. - 2009. - №76. - Р. 452-454.

25. Biomarkers of inflammation in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity and radiographic outcome /

L. S. Knudsen, M. Klarlund, H. Sk^dt et al. // J Rheumatol. - 2008. - №35. - Р. 1277-1287.

26. Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional study / W. De Jager, E.P. Hoppenreijs, N.M. Wulffraat et al. // Ann Rheum Dis. - 2007. - №66. - Р. 589-598.

27. Body iron stores and the risk of cancer / R.G. Stevens, D.Y. Jones, M.S. Micozzi, P.R. Taylor // N Engl J Med. - 1988. - №319. - Р. 1047-1052.

28. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women / R. Jiang, J.E. Manson, J.B. Meigs et al. // JAMA. - 2004. - №291. - Р. 711­717.

29. Boros, C. Juvenile idiopathic arthritis / C. Boros, B. Whitehead // Aust Fam Physician. 2010 №39(9). Р.630-636.

30. Brugnara, C. Iron deficiency and erythropoiesis: new diagnostic approaches / C. Brugnara // Clin Chem. - 2003. - №49. - Р. 1573-1578.

31. Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo / L.L.

32. Camaschella, C. BMP6 orchestrates iron metabolism / C. Camaschella // Nat Genet. - 2009. - №41. - Р. 386-388.

33. Camaschella, C. Iron and hepcidin: a story of recycling and balance / C. Camaschella // Hematology Am Soc Hematol Educ Program. - 2013. - Р.1-8.

34. Cartwright, G.E. The anaemia of chronic disorders / G.E. Cartwright, G.R. Lee // Br. J. Haematol. - 1971. - №21. - Р. 147-152.

35. Cartwright, G.E. The anemia of chronic disorders / G.E. Cartwright // Semin. Hematol. - 1966. - №3. - Р. 351-375.

36. Cartwright, G.E. The anemia of infection. XVII. A review / G.E. Cartwright,

M.M. Wintrobe // Adv. Intern. Med. - 1952. - №5. - Р. 165-226.

37. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis / I.M. De Kleer,

L. R. Wedderburn, L.S. Taams et al. // J Immunol. - 2004. - №172. - Р. 6435­6443.

38. Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia / C.R. Ruprecht, M. Gattorno, F. Ferlito et al. // J Exp Med. -

2005. - №201. - Р. 1793-1803.

39. Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis / M. Chabaud, P. Garnero, J.M. Dayer et al. // Cytokine. - 2000. - №12. - Р. 1092-1099.

40. Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis / F. De Benedetti, M. Massa, P. Robbioni et al. // Arthritis Rheum. - 1991. - №34. - Р. 1158-1163.

41. Cullis, J.O. Anaemia of chronic disease / J.O. Cullis // Clin Med. - 2013. - №13(2). - Р. 193-196.

42. Cullis, J.O. Diagnosis and management of anaemia of chronic disease: current status / J.O. Cullis // Br J Haematol. - 2011. - №154(3). - Р. 289-300.

43. Cytokine-mediated regulation of iron transport in human monocytic cells / S. Ludwiczek, E. Aigner, I. Theurl, G. Weiss // Blood.

44. Dallalio, G. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations / G. Dallalio, E. Law, R.T. Jr. Means // Blood. -

2006. - №107(7). - Р. 2702-2704.

45. Decrease of interleukin 6 during the first 12 months is a prognostic marker for clinical outcome during 36 months treatment with disease-modifying

antirheumatic drugs / R.H. Straub, U. Muller-Ladner, T. Lichtinger et al. // Br J Rheumatol. - 1997. - №36. - Р. 1298-1303.

46. Decreased erythropoietin response in patients with the anemia of cancer / C.B. Miller, R.J. Jones, S. Piantadosi et al. // N Engl J Med. - 1990. - №322. - Р. 1689-1692.

47. Defective iron supply to erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis / M. Cazzola, L. Ponchio, F. De Benedetti et al. // Blood. - 1996. - №87. - Р. 4824-4830.

48. Diagnostic potential of hepcidin testing in pediatrics / G. Cangemi, A. Pistorio,

M. Miano et al. // Eur J Haematol. - 2013. - №90(4). - Р. 323-330.

49. Differences in synovial fluid cytokine levels between juvenile and adult rheumatoid arthritis / F. De Benedetti, P. Pignatti, V. Gerloni et al. // J Rheumatol. - 1997. - №24. - Р. 1403-1409.

50. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate / R.N. Maini, P.C. Taylor, J. Szechinski et al. // Arthritis Rheum. - 2006. - №54. - Р. 2817-2829.

51. Early activation of cutaneous vessels and epithelial cells is characteristic of acute systemic onset juvenile idiopathic arthritis / M. Frosch, D. Metze, D. Foell et al. // Exp Dermatol. - 2005. - №14. - Р. 259-265.

52. Ebringer, A. HLA molecules, bacteria and autoimmunity / A. Ebringer, C. Wilson // J Med Microbiol. - 2000. - №49(4). - Р. 305-311.

53. Effect of hepcidin on intestinal iron absorption in mice / A.H.

54. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial / J.S. Smolen, A. Beaulieu, A. Rubbert-Roth et al. // Lancet. - 2008. - №371. - Р. 987-997.

55. Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietin / G. Weiss, E. Meusburger, G. Radacher et al. // Kidney Int. - 2003. - №64. - Р. 572-578.

56. Effect of recombinant human erythropoietin and intravenous iron on anemia and disease activity in rheumatoid arthritis / J.P. Kaltwasser, U. Kessler, R. Gottschalk et al. // J Rheumatol. - 2001. - №28. - Р. 2430-2436.

57. Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus / C.K. Wong, C.Y. Ho, E.K. Li, C.W. Lam // Lupus. - 2000. - №9. - Р. 589-593.

58. Endocrinopathies in transfusion-associated iron overload / M.K. Kim, J.W. Lee,

K.H. Baek et al. // Clin Endocrinol (Oxf). - 2013. - №78(2). - Р. 271-277.

59. Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines / M. Chabaud, F. Fossiez, J.L. Taupin, P. Miossec // J Immunol. - 1998. - №161. - Р. 409-414.

60. Enns, C.A. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage / C.A. Enns, R. Ahmed, A.S. Zhang // J Biol Chem. - 2012. - №287(42). - Р. 35104-35117.

61. Expression of angiogenic factors in juvenile rheumatoid arthritis: correlation with revascularization of human synovium engrafted into SCID mice / M.P. Scola, T. Imagawa, G.P. Boivin et al. // Arthritis Rheum. - 2001. - №44. - Р. 794-801.

62. Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis / M. Frosch, T. Vogl, S. Seeliger et al. // Arthritis Rheum. - 2003. - №48. - Р. 2622-2626.

63. Factors influencing quality of life (QOL) for Korean patients with rheumatoid arthritis (RA) / S.K. Cho, D. Kim, J.B. Jun et al. // Rheumatol Int. - 2013. - №33(1). - Р. 93-102.

64. Firestein, G.S. Quantitative analysis of cytokine gene expression in rheumatoid arthritis / G.S. Firestein, J.M. Alvaro-Gracia, R. Maki // J Immunol. - 1990. - №144. - Р. 3347-3353.

65. Foell, D. Proinflammatory S100 proteins in arthritis and autoimmune disease / D. Foell, J. Roth // Arthritis Rheum. - 2004. - №50. - Р. 3762-3771.

66. Forre, O. Genetic epidemiology of juvenile idiopathic arthritis / O. Forre, A. Smerdel // Scand J Rheumatol. 2002 №31. Р.123-128.

67. FOXP3+ regulatory T cells in the human immune system / S. Sakaguchi, M. Miyara, C.M. Costantino, D.A. Hafler // Nat Rev Immunol. - 2010. - №10(7). - Р. 490-500.

68. Friend of GATA and GATA-6 modulate the transcriptional up-regulation of hepcidin in hepatocytes during inflammation / E.T. Bagu, A. Layoun, A. Calve, M.M. Santos // Biometals. - 2013. - №26(6). - Р. 1051-1065.

69. Frost, A.E. Anemia and erythropoietin levels in recipients of solid organ transplants / A.E. Frost, C.A. Keller // Transplantation. - 1993. - №56. - Р. 1008-1011.

70. Fung, E. Manipulation of the hepcidin pathway for therapeutic purposes / E. Fung, E. Nemeth // Haematologica. - 2013. - №98(11). - Р. 1667-1676.

71. Ganz, T. Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages / T. Ganz // Best Pract Res Clin Haematol. - 2005. - №18(2). - Р. 171-182.

72. Ganz, T. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders / T. Ganz, E. Nemeth // Hematology Am Soc Hematol Educ Program. - 2011. - №2011. - Р. 538-542.

73. Ganz,T. Hepcidin and iron homeostasis / T. Ganz, E. Nemeth // Biochim Biophys Acta. - 2012. - №1823(9). - Р. 1434-43.

74. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci / E.A. Stahl, S. Raychaudhuri, E.F. Remmers et al. // Nat Genet. - 2010. - №42. - Р. 508-514.

75. Genome-wide association study of genetic predictors of anti-tumour necrosis factor (TNF) treatment in rheumatoid arthritis (RA) identifies associations with polymorphisms at seven loci / D. Plant, J. Bowes, C. Potter et al. // Arthritis Rheum. - 2010. - №63. - Р. 645-653.

76. Gizinski, A.M. T cell subsets and their role in the pathogenesis of rheumatic disease / A.M. Gizinski, D.A. Fox // Curr Opin Rheumatol. - 2014. - №26(2). - Р. 204-210.

77. Global prevalence of ankylosing spondylitis / L.E. Dean, G.T. Jones, A.G. Macdonald et al. // Rheumatology (Oxford). - 2013. - Dec 9. - 10 p.

78. Goodnough, L.T. Anemia, transfusion, and mortality / L.T. Goodnough, R.G. Bach // N Engl J Med. - 2001. - №345. - Р. 1272-1274.

79. Goodnough, L.T. Erythropoietin, iron, and erythropoiesis / L.T. Goodnough, B. Skikne, C. Brugnara // Blood. - 2000. - №96. - Р. 823-833.

80. Goswami, T. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron

sensing / T. Goswami, N.C. Andrews // J Biol Chem. - 2006. - №281. - Р. 28494-28498.

81. Grom, A.A. Macrophage activation syndrome: advances towards understanding pathogenesis / A.A. Grom, E.D. Mellins // Curr Opin Rheumatol. - 2010. - №22(5). - Р. 561-566.

82. Guidi, G.C. Advancements in anemias related to chronic conditions / G.C. Guidi, C. Lechi Santonastaso // Clin Chem Lab Med. - 2010. - №48(9). - Р. 1217­1226.

83. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System // World Health Organization, Geneva. - 2011. - URL: http://www.who.int/vmnis/indicators/haemoglobin.pdf

84. Hagve, T.A. Iron deficiency anaemia--interpretation of biochemical and haematological findings / T.A. Hagve, K. Lilleholt, M. Svendsen // Tidsskr Nor Laegeforen. - 2013. - №133(2). - Р. 161-164.

85. Hahn, Y.S. Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis / Y.S. Hahn, J.G. Kim // Korean J Pediatr. - 2010. - №53(11). - Р. 921­930.

86. Hashimoto, M. Role of Th17 cells and innate immunnity for the induction of autoimmune arthritis / M. Hashimoto, T. Mimori // Nihon Rinsho Meneki Gakkai Kaishi. - 2012. - №35(6). - Р. 463-469.

87. Heinrich, P.C. Interleukin-6 and the acute phase response / P.C. Heinrich, J.V. Castell, T. Andus // Biochem J. - 1990. - №265. - Р. 621-636.

88. Henry, D. Prediction of response to recombinant human erythropoietin (r- HuEPO/epoetin-alpha) therapy in cancer patients / D. Henry, R. Abels, K. Larholt // Blood. - 1995. - №85. - Р. 1676-1678.

89. Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-KB-dependent signaling / J.G. Bode, U. Albrecht, D. Haussinger et al. // Eur J Cell Biol. - 2012. - №91(6-7). - Р. 496-505.

90. Hepatic iron overload induces hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein / T. Furutani, K. Hino, M. Okuda et al. // Gastroenterology. - 2006. - №130(7). - Р. 2087-2098.

91. Hepcidin and HFE protein: Iron metabolism as a target for the anemia of chronic kidney disease / E. Canavesi, C. Alfieri, S. Pelusi, L. Valenti // World J Nephrol. - 2012. - №1(6). - Р. 166-176.

92. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6 / R. Rodriguez, C.L. Jung, V. Gabayan et al. // Infect Immun. - 2014. - №82(2). - Р. 745-752.

93. Hepcidin production in response to iron is controlled by monocyte-derived humoral factors / Y. Sasaki, Y. Shimonaka, K. Ikuta et al. // Int J Hematol. - 2014. - №99(1). - Р. 12-20.

94. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization / E. Nemeth, M.S. Tuttle, J. Powelson et al. // Science. - 2004. - №306. - Р. 2090-2093.

95. Hepcidin regulation by innate immune and infectious stimuli / A.E. Armitage,

L. A. Eddowes, U. Gileadi et al. // Blood. - 2011. - №118(15). - Р. 4129-4139.

96. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein / E. Nemeth, E.V. Valore, M. Territo et al. // Blood. - 2003. - №101. - Р. 2461-2463.

97. Hepcidin, a urinary antimicrobial peptide synthesized in the liver / C.H. Park, E.V. Valore, A.J. Waring, T. Ganz // J Biol Chem. - 2001. - №276(11). - Р. 7806-7810.

98. Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2- macroglobulin in blood / G. Peslova, J. Petrak, K. Kuzelova et al. // Blood. - 2009. - №113. - Р. 6225-6236.

99. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin / T. Tanno, N.V. Bhanu, P.A. Oneal et al. // Nat Med. - 2007. - №13. - Р. 1096-1101.

100. Highly elevated serum levels of interleukin-18 in systemic juvenile idiopathic arthritis but not in other juvenile idiopathic arthritis subtypes or in Kawasaki disease / N. Maeno, S. Takei, Y. Nomura et al. // Arthritis Rheum. - 2002. - №46. - Р. 2539-2541.

101. Hori, S. Control of regulatory T cell development by the transcription factor Foxp3 / S. Hori, T. Nomura, S. Sakaguchi // Science. - 2003. - №299. - Р. 1057­1061.

102. Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells / E.A. Moseman, X. Liang, A.J. Dawson et al. // Journal of Immunology. - 2004. - Vol.173, №7. - Р. 4433-4442.

103. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis / S. Kotake, N. Udagawa, N. Takahashi et al. // J Clin Invest. - 1999. - №103. - Р. 1345-1352.

104. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis / Y. Komiyama, S. Nakae, T. Matsuki et al. // J. Immunol. -

2006. - №177. - Р. 566-573.

105. IL-17 stimulates the production and expression of proinflammatory cytokines, IL- 1в and TNF-a, by human macrophages / D.V. Jovanovic, J.A. Di Battista, J. Martel-Pelletier et al. // J Immunol. - 1998. - №160. - Р. 3513-3521.

106. IL-6 - STAT-3 - hepcidin: linking inflammation to the iron metabolism / I. Stoian, B. Manolescu, V. Atanasiu et al. // Rom J Intern Med. - 2007. - №45(3). - Р. 305-309.

107. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin / E. Nemeth, S. Rivera, V. Gabayan et al. // J Clin Invest. - 2004. - №113. - Р. 1271-1276.

108. Il-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: results from a 24-week multicentre randomised placebo controlled trial / P. Emery, E. Keystone, H.P. Tony et al. // Ann Rheum Dis. - 2008. - №67. - Р. 1516-1523.

109. Immunoassay for human serum hepcidin / T. Ganz, G. Olbina, D. Girelli et al. // Blood. - 2008. - №112. - Р. 4292-4297.

110. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance / S. Sakaguchi, N. Sakaguchi, J. Shimizu et al. // Immunol Rev. - 2001. - №182. - Р. 18-32.

111. Impaired skeletal development in interleukin-6-transgenic mice. A model for the impact of chronic inflammation on the growing skeletal system / F. De Benedetti, N. Rucci, A. Del Fattore et al. // Arthritis Rheum. - 2006. - №54. - Р. 3551­3563.

112. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease / D.A. Weinstein, C.N. Roy, M.D. Fleming et al. // Blood. - 2002. - №100. - Р. 3776-3781.

113. Increased expression of interleukin 17 in inflammatory bowel disease / S. Fujino, A. Andoh, S. Bamba et al. // Gut. - 2003. - №52. - Р. 65-70.

114. Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor / X. Alvarez-Hernandez, J. Liceaga, I.C. McKay, J.H. Brock / Lab Invest. - 1989. - №61. - Р. 319-322.

115. Inflammation Regulates TMPRSS6 Expression via STAT5 / D. Meynard, C.C. Sun, Q. Wu et al. // PLoS One. - 2013. - №8(12) - e82127. - 10р.

116. Inflammatory regulation of iron metabolism during thioacetamide-induced acute liver injury in rats / T. Izawa, H. Murakami, K.K. Wijesundera et al. // Exp Toxicol Pathol. - 2014. - №66(2-3). - Р. 155-162.

117. Influence of a recombinant human soluble tumor necrosis factor receptor Fc fusion protein on type II collagen-induced arthritis in mice / P.H. Wooley, J. Dutcher, M.B. Widmer, S. Gillis // J Immunol. - 1993. - №151. - Р. 6602-6607.

118. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression / J. Gao, J. Chen, M. Kramer et al. // Cell Metab. - 2009. - №9. P. 217-227.

119. Interferon gamma downregulates stem cell factor and erythropoietin receptors but not insulin-like growth factor-I receptors in human erythroid colony-forming cells / S. Taniguchi, C.H. Dai, J.O. Price, S.B. Krantz // Blood. - 1997. - №90. - Р. 2244-2252.

120. Interleukin 10 cooperates with interleukin 4 to suppress inflammatory cytokine production by freshly prepared adherent rheumatoid synovial cells / E. Sugiyama, A. Kuroda, H. Taki et al. // J Rheumatol. - 1995. - №22. - Р. 2020-2026.

121. Interleukin-17 / F. Fossiez, J. Banchereau, R. Murray et al. // Int Rev Immunol. - 1998. - №16. - Р. 541 -551.

122. Interleukin-17 family and IL-17 receptors / T.A. Moseley, D.R. Haudenschild, L. Rose, A.H. Reddi // Cytokine Growth Factor Rev. - 2003. - №14. - Р. 155-174.

123. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis / J.S. Tzartos, M.A. Friese, M.J. Craner et al. // Am. J. Pathol. - 2008. - №172. - Р. 146-155.

124. Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease / Y. Kawaguchi, H. Terajima, M. Harigai et al. // Arthritis Rheum. - 2001. - №44. - Р. 1716-1717.

125. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation / S. Kotake, K. Sato, K.J. Kim et al. // J Bone Miner Res. - 1996. - №11. - Р.88-95.

126. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer / S. Rose-John, J. Scheller, G. Elson, Jones SA. // J Leukoc Biol. - 2006. - №80. - Р.227-236.

127. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inad- equate response to disease-modifying antirheumatic drugs / M.C. Genovese, J.D. McKay, E.L. Nasonov et al. // Arthritis Rheum. - 2008. - №58. - Р. 2968-2980.

128. Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter, open-label, randomized trial / M. Auerbach, H. Ballard, J.R. Trout et al. // J Clin Oncol. - 2004. - №22. - Р. 1301-1307.

129. Iron refractory iron deficiency anemia / L. De Falco, M. Sanchez, L. Silvestri et al. // Haematologica. - 2013. - №98(6). - Р. 845-853.

130. Iron release from human monocytes after erythrophagocytosis in vitro: an investigation in normal subjects and hereditary hemochromatosis patients / E. Moura, M.A. Noordermeer, N. Verhoeven et al. // Blood. - 1998. - №92. -Р. 2511-2519.

131. Iron status and the outcome of HIV infection: an overview / V.R. Gordeuk, J.R. Delanghe, M.R. Langlois, J.R. Boelaert // J Clin Virol. - 2001. - №20. - Р. 111­115.

132. Iron storage indices: novel predictors of bacteremia in hemodialysis patients initiating intravenous iron therapy / G.S. Teehan, D. Bahdouch, R. Ruthazer et al. // Clin Infect Dis. - 2004. - №38. - Р. 1090-1094.

133. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 / L. Lin, E.V. Valore, E. Nemeth et al. // Blood. -

2007. - №110. - Р. 2182-2189.

134. Jelkmann, W. Proinflammatory cytokines lowering erythropoietin production / W. Jelkmann // J Interferon Cytokine Res. - 1998. - №18. - Р. 555-559.

135. Jones, G. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION Study / G. Jones, A. Sebba, J. Gu // Ann Rheum Dis. - 2010. - №69. - Р. 88-96.

136. Juvenile idiopathic systemic arthritis / D. Baksiene, J. Kasparaviciene, M. Zebiene, B. Puteliene // Medicina (Kaunas). - 2003. - №39(8). - Р. 751-755.

137. Juvenile rheumatoid arthritis in affected sib-pairs / M.B. Moroldo, B.L. Tague, E.S. Shear et al. // Arthritis Rheum. - 1997. - №40. - Р. 1962-1966.

138. Kanwar, P. Diagnosis and treatment of hereditary hemochromatosis: an update / P. Kanwar, K.V. Kowdley // Expert Rev Gastroenterol Hepatol. - 2013. - №7(6). - Р. 517-530.

139. Katz, Y. Interleukin-17 enhances tumor necrosis factor а-induced synthesis of interleukins 1, 6, and 8 in skin and synovial fibroblasts: a possible role as a “fine­tuning cytokine” in inflammation processes / Y. Katz, O. Nadiv, Y. Beer // Arthritis Rheum. - 2001. - №44. - Р. 2176-2184.

140. Kletzmayr, J. High dose intravenous iron: a note of caution / J. Kletzmayr, G. Sunder-Plassmann, W.H. Horl // Nephrol Dial Transplant. - 2002. - №17. - Р. 962-965.

141. Kolls, J.K. Interleukin-17 family members and inflammation / J.K. Kolls, A. Linden // Immunity. - 2004. - №21. - Р. 467-476.

142. Kutukculer, N. Study of pro-inflammatory (TNF-a, IL-1a, IL-6) and T-cell- derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: correlations with clinical and laboratory parameters / N. Kutukculer, S. Caglayan, F. Aydogdu // Clin Rheumatol. - 1998. - №17. - Р. 288-292.

143. Lambing, A. The dangers of iron overload: bring in the iron police / A. Lambing, E. Kachalsky, M.L. Mueller // J Am Acad Nurse Pract. - 2012. - №24(4). - Р. 175-183.

144. Leirisalo-Repo, M. Early arthritis and infection / M. Leirisalo-Repo // Curr Opin Rheumatol. - 2005. - №17(4). - Р. 433-439.

145. Leitman, S.F. Hemochromatosis: the new blood donor / S.F. Leitman // Hematology Am Soc Hematol Educ Program. - 2013. - Vol. 2013, №1. - Р. 645-650.

146. Lipschitz, D.A. A clinical evaluation of serum ferritin as an index of iron stores / D.A. Lipschitz, J.D. Cook, C.A. Finch // N Engl J Med. - 1974. - №290. - Р. 1213-1216.

147. Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice / V. Diaz, E. Gammella, S. Recalcati et al. // Hepatology. - 2013. - №58(6). - Р. 2122-2132.

148. Locke, A. The copper and non-hemoglobinous iron contents of the blood serum in disease / A. Locke, E.R. Main, D.O. Rosbach // J. Clin. Invest. - 1932. - №11. - Р. 527-542.

149. Masson, C. Rheumatoid anemia / C. Masson // Joint Bone Spine. - 2011. - №78(2). - Р. 131-137.

150. Means, R.T. Jr. Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin / R.T. Jr Means, S.B. Krantz // Blood. - 1991. - №78. - Р. 2564-2567.

151. Means, R.T. Jr. Recent developments in the anemia of chronic disease / R.T. Jr Means // Curr Hematol Rep. - 2003. - №2. - Р. 116-121.

152. Means, R.T. Pathogenesis of the anemia of chronic disease: a cytokine-mediated anemia / R.T. Means // Stem Cells. - 1995. - №13. - Р. 32-37.

153. Michels-van Amelsfort, J.M. CD4+CD25+ regulatory T cells in systemic sclerosis and other rheumatic diseases / J.M. Michels-van Amelsfort, G.J. Walter, L.S. Taams // Expert Rev Clin Immunol. - 2011. - №7(4). - Р. 499-514.

154. Miyazawa, K. IL-6 synthesis by rheumatoid synoviocytes is autonomously upregulated at the transcriptional level / K. Miyazawa, A. Mori, H. Okudaira // J Allergy Clin Immunol. - 1999. - №103. - Р. S437-444.

155. Molnar-Kimber, K.L. Each type of cause that initiates rheumatoid arthritis or RA flares differentially affects the response to therapy / K.L. Molnar-Kimber, C.T. Kimber // Medical Hypotheses. - 2012. - №78. - Р. 123-129.

156. Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations / D. Foell, H. Wittkowski, I. Hammerschmidt et al. // Arthritis Rheum. - 2004. - №50. - Р. 1286-1295.

157. Murray, K. Pathogenesis of juvenile chronic arthritis: genetic and environmental factors / K. Murray, S.D. Thompson, D.N. Glass // Arch Dis Child. - 1997. - №77. - Р. 530-534.

158. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis / G. Papanikolaou, M.E. Samuels, E.H. Ludwig et al. // Nat Genet. - 2004. - №36. - Р. 77-82.

159. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation / T. Korn, J. Reddy, W. Gao et al. // Nat Med. - 2007. - №13. - Р. 423-431.

160. Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells / D. Viemann, A. Strey, A. Janning et al. // Blood. - 2005. - №105. - Р. 2955-2962.

161. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome / J. Villanueva, S. Lee, E.H. Giannini et al. // Arthritis Res Ther. - 2005. - №7. - Р. R30-37.

162. Nemeth, E. The role of hepcidin in iron metabolism / E. Nemeth, T. Ganz // Acta Haematol. - 2009. - №122(2-3). - Р. 78-86.

163. Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis / D.H. Lee, L.J. Zhou, Z. Zhou et al. // Blood. - 2010. - №115(15). - Р. 3136-3145.

164. Nepom, B.S. Juvenile rheumatoid arthritis and HLA: report of the Park City III workshop / B.S. Nepom, D.N. Glass // J Rheumatol Suppl. - 1992. - №33. - Р. 70-74.

165. Niederkofler, V. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload / V. Niederkofler, R. Salie, S. Arber // J Clin Invest. - 2005. - №115. - Р. 2180-2186.

166. Nishimoto, N. Interleukin 6: from bench to bedside / N. Nishimoto, T. Kishimoto // Nat Clin Pract Rheumatol. - 2006. - №2. - Р. 619-626.

167. Nitric oxide suppression of human hematopoiesis in vitro: contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha / J.P. Maciejewski, C. Selleri, T. Sato et al. // J Clin Invest. - 1995. - №96. - Р. 1085­1092.

168. NKF-K/DOQI Clinical Practice Guidelines for anemia of chronic kidney disease: update 2000 // Am J Kidney Dis. - 2001. - №37, Suppl 1. - Р. S182-S238.

169. Oligoarticular juvenile idiopathic arthritis among Saudi children / M.M. Moued, H.M. Al-Saggaf, H.S. Habib, M.A. Muzaffer // Ann Saudi Med. - 2013. - №33(6). - Р. 529-532.

170. Oustamanolakis P, Koutroubakis IE, Kouroumalis EA. Diagnosing anemia in inflammatory bowel disease: beyond the established markers / P. Oustamanolakis, I.E. Koutroubakis, E.A. Kouroumalis // J Crohns Colitis. - 2011. - №5(5). - Р. 381-91.

171. Pablos Alvarez, J.L. Interleukin 6 in the physiopathology of rheumatoid arthritis /

J.L.Pablos Alvarez // Reumatol Clin. - 2009. - №5(1). - Р. 34-39.

172. Pasare, C. Toll pathway-dependent blockade of CD4+ CD25+ T cell-mediated suppression by dendritic cells / C. Pasare, R. Medzhitov // Science. - 2003. - №299. - Р. 1033-1036.

173. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease / K. Yoshizaki, T. Matsuda, N. Nishimoto et al. // Blood. - 1989. - №74. - Р. 1360­1367.

174. Patterns of expression of tumor necrosis factor a, tumor necrosis factor в, and their receptors in synovia of patients with juvenile rheumatoid arthritis and juvenile spondylarthropathy / A.A. Grom, K.J. Murray, L. Luyrink et al. // Arthritis Rheum. - 1996. - №39. - Р. 1703-1710.

175. Pettipher, E.R. Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint / E.R. Pettipher, G.A. Higgs, B. Henderson // Proc Natl Acad Sci U S A. - 1986. - №83. - Р. 8749-8753.

176. Phagocyte specific S100 proteins: a novel group of proinflammatory molecules /

J. Roth, T. Vogl, C. Sorg, C. Sunderkotter // Trends Immunol. - 2003. - №24. - Р. 155-158.

177. Phelan, J. Genomic progress in pediatric arthritis: recent work and future goals / J. Phelan, S. Thompson // Curr Opin Rheumatol. - 2006. - №18. - Р. 482-489.

178. Phenotypic and functional characterization of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis / M. Gattorno, I. Prigione, F. Moranti et al. // Arthritis Res Ther. - 2005. - №7. - Р. R256-R267.

179. Pietrangelo, A. Physiology of iron transport and the hemochromatosis gene / A. Pietrangelo // Am J Physiol Gastrointest Liver Physiol. - 2002. - №282. - Р. G403-G414.

180. Polymorphichaplotypes of the interleukin-10 50 flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis / E. Crawley, R. Kay, J. Sillibourne et al. // Arthritis Rheum. - 1999. - №42. - Р. 1101-1108.

181. Potential relationship between herpes viruses and rheumatoid arthritis: analysis with quantitative real time polymerase chain reaction / R. Alvarez-Lafuente, B. Fernandez-Gutierrez, S. de Miguel et al. // Ann Rheum Dis. - 2005. - №64. - Р. 1357-1359.

182. Prediction of response to erythropoietin treatment in chronic anemia of cancer / H. Ludwig, E. Fritz, C. Leitgeb et al. // Blood. - 1994. - №84. - Р. 1056-1063.

183. Prediction of response to iron sucrose in inflammatory bowel disease-associated anemia / C. Gasche, T. Waldhoer, T. Feichtenschlager et al. // Am J Gastroenterol. - 2001. - №96. - Р. 2382-2387.

184. Prevalence and causes of anemia in elderly hospitalized patients / Y. Matzner, S. Levy, N. Grossowicz et al. // Gerontology. - 1979. - №25. - Р. 113-119.

185. Prevalence and outcome of anemia in rheumatoid arthritis: a systematic review of the literature / A. Wilson, H.T. Yu, L.T. Goodnough, A.R. Nissenson // Am J Med. - 2004. - №116, Suppl.7A. - Р. 50S-57S.

186. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia / J.M. Guralnik, R.S. Eisenstaedt, L. Ferucci et al. // Blood. - 2004. - №104. - Р. 2263-2268.

187. Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4 / J.A.G. van Roon, J.L.A.M. van Roy, F.H.J. Gmelig-Meyling et al. // Arthritis Rheum. - 1996. - №39. - Р. 829-835.

188. Proinflammatory cytokine production and cartilage damage due to rheumatoid synovial T helper-1 activation is inhibited by interleukin-4 / J.A.G. van Roon, J.L.A.M. van Roy, A. Duits et al. // Ann Rheum Dis. - 1995. - №54. - Р. 836­840.

189. Punnonen, K. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency / K. Punnonen, K. Irjala, A. Rajamaki // Blood. - 1997. - №89. - Р. 1052-1057.

190. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin / Y. Beguin, G.K. Clemons, P. Pootrakul, G. Fillet // Blood. - 1993. - №81. - Р. 1067-1076.

191. Raj, D.S. Role of interleukin-6 in the anemia of chronic disease / D.S. Raj // Semin Arthritis Rheum. - 2009. - №38. - Р. 382-388.

192. Ravelli, A. Juvenile idiopathic arthritis / A. Ravelli, A. Martini / Lancet. - 2007. - №369. - Р. 767-778.

193. Recombinant human erythropoietin improves health-related quality of life in patients with rheumatoid arthritis and anaemia of chronic disease; utility measures correlate strongly with disease activity measures / H.R. Peeters, M. Jongen-Lavrencic, C.H. Bakker et al. // Rheumatol Int. - 1999. - №18(5-6). - Р.201-206.

194. Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation / N.M. Wulffraat, G.T. Rijkers, E. Elst et al. // Rheumatology. - 2003. - №42. - Р. 375-379.

195. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) / C. Peyssonnaux, A.S. Zinkernagel, R.A. Schuepbach et al. // J Clin Invest. - 2007. - №117. - Р. 1926-1932.

196. Role of hepcidin in murine brain iron metabolism / S.M. Wang, L.J. Fu, X.L. Duan et al. // Cell Mol Life Sci. - 2010. - №67(1). - Р. 123-33.

197. Role of IL-10 for induction of anemia during inflammation / H. Tilg, H. Ulmer, A. Kaser, G. Weiss // J Immunol. - 2002. - №169. - Р. 2204-2209.

198. Role of interleukin (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade / V. Pascual, F. Allantaz, E. Arce et al. // J Exp Med. - 2005. - №201. - Р. 1479-1486.

199. Rosen, P. Non-HLA gene polymorphisms in juvenile rheumatoid arthritis / P. Rosen, S. Thompson, D. Glass // Clin Exp Rheumatol. - 2003. - №21. - Р. 650­656.

200. Selective recruitment of polarized T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis / L.R. Wedderburn, N. Robinson, A. Patel et al. // Arthritis Rheum. - 2000. - №43. - Р. 765-774.

201. Serum cytokines in juvenile rheumatoid arthritis. Correlation with conventional inflammation parameters and clinical subtypes / H. Mangge, H. Kenzian, S. Gallistl et al. // Arthritis Rheum. - 1995. - №38. - Р. 211-220.

202. Serum hepcidin: reference ranges and biochemical correlates in the general population / T.E. Galesloot, S.H. Vermeulen, A.J. Geurts-Moespot et al. // Blood.

- 2011. - №117(25). - Р. 218-225.

203. Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis / F. De Benedetti, M. Massa, P. Pignatti et al. // J Clin Invest. - 1994. - №93. - Р. 2114-2119.

204. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin / G. Nicolas, M. Bennoun, A. Porteu et al. // Proc Natl Acad Sci USA. - 2002. - №99. - Р. 4596-4601.

205. Shander, A. Iron overload and toxicity: the hidden risk of multiple blood transfusions / A. Shander, M.D. Cappellini, L.T. Goodnough / Vox Sang. - 2009.

- №97(3). - Р. 185-197.

206. Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes / L.C. Tan, A.G. Mowat, C. Fazou et al. // Arthritis Res. - 2000. - №2. - Р. 154-164.

207. Spivak, J.L. Iron and the anemia of chronic disease / JL. Spivak // Oncology (Huntingt). - 2002. - №16, Suppl 10. - Р. 25-33.

208. Sugino, H. DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies / H. Sugino, H.M. Lee, N. Nishimoto // Arthritis Res Ther. - 2010. - №12. - Р. 401.

209. Sullivan, J.L. Iron therapy and cardiovascular disease / J.L. Sullivan // Kidney Int Suppl. - 1999. - №69. - Р. S135-S137.

210. Suppression of hepcidin during anemia requires erythropoietic activity / M. Pak,

M.A. Lopez, V. Gabayan et al. // Blood. - 2006. - №108. - Р. 3730-3735.

211. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice / S. Nakae, A. Nambu, K. Sudo, Y. Iwakura // J Immunol. - 2003. - №171. - Р. 6173-6177.

212. Synovial expression of osteopontin correlates with angiogenesis in juvenile idiopathic arthritis / M. Gattorno, A. Gregorio, F. Ferlito et al. // Rheumatology. - 2004. - №43. - Р. 1091-1096.

213. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs / S. Rivera, E. Nemeth, V. Gabayan et al. // Blood. - 2005. - №106. - Р. 2196-2199.

214. Tang, Q. The Foxp3+ regulatory T cell: a jack of all trades, master of regulation / Q. Tang, JA. Bluestone // Nat Immunol. - 2008. - №9(3). - Р.239-244.

215. Th17 functions as an osteoclastogenic helper T cells subset that links T cell activation and bone destruction / K. Sato, A. Suematsu, K. Okamoto et al. // J Exp Med. - 2006. - №203. - Р. 2673-2682.

216. Th17: an effector of CD4 T cell lineage with regulatory T cell ties / C.T. Weaver, L.E. Harrington, P.R. Mangan et al. // Immunity. - 2006. - №24. - Р. 677-688.

217. The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells / M. Shingu, Y. Nagai, T. Isayama et al. // Clin Exp Immunol. - 1993. - №94. - Р. 145-149.

218. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation / G. Nicolas, C. Chauvet, L. Viatte et al. // J Clin Invest. - 2002. - №110(7). - Р. 1037-1044.

219. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 / C.L. Bennett, J. Christie, F. Ramsdell et al. // Nat Genet. - 2001. - №27. - Р. 20-21.

220. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis / A. Donovan, C.A. Lima, J.L. Pinkus et al. // Cell Metab. - 2005. - №1. - Р. 191­200.

221. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney / H. Kulaksiz, F. Theilig, S. Bachmann et al. // J Endocrinol. - 2005. - №184. - Р. 361-370.

222. The molecular basis of hepcidin-resistant hereditary hemochromatosis / A. Fernandes, G.C. Preza, Y. Phung et al. // Blood. - 2009. - №114. - Р. 437-443.

223. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study / E. Nemeth, G.C. Preza, C.L. Jung et al. // Blood. - 2006. - №107. - Р. 328-333.

224. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic onset juvenile idiopathic arthritis / S. Yokota, T. Miyamae, T. Imagawa et al. // Arthritis Rheum. - 2005. - №52. - Р. 818-825.

225. Torti, F.M. Regulation of ferritin genes and protein / F.M. Torti, SV. Torti // Blood. - 2002. - №99. - Р. 3505-3516.

226. Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway / M.B. Johnson, J. Chen, N. Murchison et al. // Mol Biol Cell. - 2007. - №18. - Р.743-754.

227. Transfusion suppresses erythropoiesis and increases hepcidin in adult patients with в-thalassemia major: a longitudinal study / S.R. Pasricha, D.M. Frazer, D.K. Bowden, G.J. Anderson // Blood. - 2013. - №122(1). - Р. 124-133.

228. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis / J. Keffer, L. Probert, H. Cazlaris et al. // EMBO J. - 1991. - №10. - Р. 4025-4031.

229. Treatment with a neutralizing anti-murine IL-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction and bone erosion / E. Lubberts, M.I. Konders, B. Oppers-Walgreen et al. // Arthritis Rheum. - 2004. - №50. - Р. 650-659.

230. Treatment with infliximab plus methotrexate improves anemia in patients with rheumatoid arthritis independent of improvement in other clinical outcome measures - a pooled analysis from three large, multicenter, double-blind, randomized clinical trials / M.K. Doyle, M.U. Rahman, C. Han et al. // Semin Arthritis Rheum. - 2008. - №39. - Р. 123-131.

231. Tubular reabsorption and local production of urine hepcidin-25 / H.P. Peters, C.M. Laarakkers, P. Pickkers et al. // BMC Nephrol. - 2013. - №14. - Р. 70.

232. Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives / N. Costa, O. Marques, S. Godinho et al. // Ann Rheum Dis. - 2014. - №73, Suppl 1. - Р. A44.

233. Uchiyama, Y. Anemia in monkey collagen-induced arthritis is correlated with serum IL-6, but not TNFalpha / Y. Uchiyama, N. Koike, M. Mihara // Rheumatol Int. - 2008. - №28(9). - Р. 879-883.

234. Use of agents stimulating erythropoiesis in digestive diseases / R. Moreno Lopez, B. Sicilia Aladren, F. Gomollon Garcia // World J Gastroenterol. - 2009. - №15. - Р. 4675-4685.

235. Use of epoetin in patients with cancer: evidence- based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology / J.D. Rizzo, A.E. Lichtin, S.H. Woolf et al. // J Clin Oncol. - 2002. - №20. - Р. 4083-4107.

236. Validity and predictive ability of the juvenile arthritis disease activity score based on CRP versus ESR in a Nordic population-based setting / E.B. Nordal, M. Zak,

K. Aalto et al. //Ann Rheum Dis. - 2012. - №71. - P. 1122-1127.

237. Valore, E.V. Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin / E.V. Valore, T. Ganz // Blood Cells Mol Dis. - 2008. - №40. - Р. 132-138.

238. Vamvakas, E.C. Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? / E.C. Vamvakas, M.A. Blajchman / Blood. - 2001. - №97. - Р. 1180-1195.

239. Villarroel, P. Interleukin-6 and lipopolysaccharide modulate hepcidin mRNA expression by HepG2 cells / P. Villarroel, S. Le Blanc, M. Arredondo // Biol Trace Elem Res. - 2012. - №150(1-3). - Р. 496-501.

240. Vyoral, D. Hepcidin: a direct link between iron metabolism and immunity / D. Vyoral, J. Petrak // Int J Biochem Cell Biol. - 2005. - №37(9). - Р. 1768-1773.

241. Wang, C.Q. Interferon- gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development / C.Q. Wang,

K.B. Udupa, D.A. Lipschitz // J Cell Physiol. - 1995. - №162. - Р. 134-138.

242. Ware, H.M. Evaluation and treatment of transfusional iron overload in children / H.M. Ware, J.L. Kwiatkowski // Pediatr Clin North Am. - 2013. - №60(6). - Р. 1393-1406.

243. Weinberg, E.D. Iron loading and disease surveillance / E.D. Weinberg // Emerg Infect Dis. - 1999. - №5. - Р. 346-352.

244. Weiss, G. Anaemia in inflammatory rheumatic diseases / G. Weiss, G. Schett // Nat Rev Rheumatol. - 2013. - №9(4). - Р. 205-215.

245. Weiss, G. Anemia of chronic disease / G. Weiss, L.T. Goodnough // N Engl J Med. - 2005. - №352(10). - Р. 1011-1023.

246. Weiss, G. Iron and immunity: a double-edged sword / G. Weiss/ / Eur J Clin Invest. - 2002. - №32, Suppl 1. - Р. 70-78.

247. Weiss, G. Iron metabolism in the anemia of chronic disease / G. Weiss // Biochim Biophys Acta. - 2009. - №1790(7). - Р. 682-693.

248. Weiss, G. Pathogenesis and treatment of anaemia of chronic disease / G. Weiss // Blood Rev. - 2002. - №16(2). - Р. 87-96.

249. Williams, R.O. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis / R.O. Williams, M. Feldmann, R.N. Maini // Proc Natl Acad Sci U S A. - 1992. - №89. - Р. 9784-9788.

250. Wing, K. Regulatory T cells exert checks and balances on self tolerance and autoimmunity / K. Wing, S. Sakaguchi // Nat. Immunol. - 2010. - №11. - Р 7­13.

251. Winn, R.J. The NCCN guidelines development process and infrastructure / R.J. Winn // Oncology (Huntingt). - 2000. - №14. - Р. 26-30.

252. Yap, G.S. Inhibition of in vitro erythropoiesis by soluble mediators in Plasmodium chabaudi AS malaria: lack of a major role for interleukin 1, tumor necrosis factor alpha, and gamma interferon / G.S. Yap, M.M. Stevenson // Infect Immun. - 1994. - №62. - Р. 357-362.

253. Zechel, S. Distribution of the iron-regulating protein hepcidin in the murine central nervous system / S. Zechel, K. Huber-Wittmer, O. von Bohlen Halbach // J Neurosci Res. - 2006. - №84(4). - Р. 790-800.

254. Zhang, X. Beyond anemia: hepcidin, monocytes and inflammation / X. Zhang, B.H. Rovin // Biol Chem. - 2013. - №394(2). - Р. 1-10.

255. Zhang, X. Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines / X. Zhang, B.H. Rovin // Biochim Biophys Acta. - 2010. - №1800. - Р. 1262-1267.

256. Zhao, N. Iron regulation by hepcidin / N. Zhao, A.S. Zhang, C.A. Enns // J Clin Invest. - 2013. - №123(6). - Р. 2337-2343.