<<

  СПИСОК ЛИТЕРАТУРЫ  

  Muzzarelli R.A.A. Chitin. Oxford: Pergamon Press., 1977. - P.309.
  • Cauchie H-M. Chitin production by arthropods in the hydrosphere // Hydrobiologia. - 2002. - V.470.
    - №1/3. - P.63-95.
    1. Majeti N.V., Kumar R. A review of chitin and chitosan applications // Reactive amp; Functional Polymers. - 2000. - V.46. - №1. - P. 1-27.
    2. Tolaimate A., Desbrie'res J., Rhazi M., Alagui A., Vincendon M., Vottero P. On the influence of deacetylation process on the physicochemical characteristics of chitosan from squid chitin // Polymer. - 2001. - V.4. - №7. -P.2463-2469.
    3. Zhang M., Haga A., Sekiguchi H., Hirano S. Structure of insect chitin isolated from beetle larva cuticle and silkworm (Bombyx mori) pupa exuvia // Int. J. Biological Macromolecules. - 2000.-V.27. - №.1. - P.99-105.
    4. Muzzarelli R.A.A. The discovery of chitin a gt; 570 Mega year old polymer // In: Chitosan in pharmacy and chemistry / Ed. R.A.A Muzzarelli, C. Muzzarelli. Atec, Italy, 2002.-P. 1-8.
    5. Тиунова H.A. Хитинолитические ферменты микроорганизмов // Успехи биологической химии. -1989. - Т.30. - №4 - С. 199-219
    6. Kumar G., Bristowa J.F., Smith P.J., Payne G.F. Enzymatic gelation of the natural polymer chitosan // Polymer. - 2000. - V.41. - №6. - P.2157-2168.
    7. Juang R-S., Shao H-J. A simplified equilibrium model for sorption of heavy metal ions from aqueous solutions on chitosan // Water Research -2002. - V.36. - №12. - P.2999-3008.
    8. Lim S.H., Hudson S.M. Application of a fiber-reactive chitosan derivative to cotton fabric as a zero-salt dyeing auxiliary // Color. Technol. -2004.-V.120.-№8-P.108-113.
    9. Smith J., Wood E., Dornish M. Effect of chitosan on epithelial cell tight junctions // Pharmaceutical Research.
      - 2004. - V.21. - №1. - P.43-49.
    10. Hejazi R., Amiji M. Chitosan - based gastrointestinal delivery systems

    117

    // J. Control Release. - 2003. - V.89. - №2. - P. 151-165.

    1. Sarasam A.R, Krishnaswamy R.K, Madihally S.V. Blending chitosan with polycaprolactone: effects on physicochemical and antibacterial properties // Biomacromolecules. - 2006. - V.7. - №4. _ p.i 131—1138.
    2. Yancheva E., Paneva D., Maximova V., Mespouille L., Dubois P., Manolova N., Rashkov I. Polyelectrolyte complexes between (cross-linked) N-carboxyethylchitosan and (quaternized) poly [2-(dimethylamino)ethyl methacrylate]: preparation, characterization, and antibacterial properties // Biomacromolecules. - 2007. - V.8. - №3.. p.976-984.
    3. Chen R., Okamoto H., Danjo K. Particale design using a 4-fluid-nozzle spray-drying technique for sustained release of acetaminophen // Chem. Pharm. Bull. 2006. V. 54. № 7. P. 948 - 953
    4. Okamoto H., Danjo K. Local and systemic delivery of high-molecular weight drugs by powder inhalation // Yakugaku Zasshi. - 2007. - V.127. - №4. - P.643-653.
    5. Kato Y., Onishi H., Machida Y. Application of chitin and chitosan derivatives in the pharmaceutical field // Curr. Pharm. Biotechnol. - 2003. - V.4. - №5. -P.303-309.
    6. Smith J., Wood E., Dornish M. Effect of chitosan on epithelial cell tight junctions // Pharmaceutical Reseach. - 2004. - V.21. - №1. - P.43-49.
    7. Xie W., Xu P., Wang W., Liu Q. Preparation of water-soluble chitosan derivatives and their antibacterial activity // J. Appl. Polym. Sci. - 2002. - V.85. -№8.-P.1357-1361.
    8. Cho Y-W., Cho Y-N., Chung S-H., Yoo G., Ко S-W. Water-soluble chitin as a wound healing accelerator // Biomaterials. - 1999. - V.20. - №22. - P.2139-2145.
    9. Liu H., Mao J., Yao K., Yang G., Cui L., Cao Y. A study on a chitosan gelatin-hyaluronic acid scaffold as artificial skin in vitro and its tissue engineering applications // J.
      Biomater. Sci. Polym. Ed. - 2003. - V.14. - №1. -P.25-40.

    118

    1. Ishak R.A., Awad G.A., Mortada N.D., Nour S.A. Preparation, in vitro and in vivo evaluation of stomach-apecific metronidozol-loaded alginate beads as local anti-Helicobacterpylori therapy // J. Control Release. - 2007. - V.3. - №1. - P.134-140.
    2. Jagur-Grodzinski J. Biomedical application of functional polymers // Reactive amp; Functional Polymers. - 1999. - V.39. - №2. - P.99-138.
    3. Ikinci G., Senel S., Akincibay H., Kas S., Ercis S., Wilson C.G., Hincal A.A. Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis II Int. J. Pharm. - 2007. - V.253. - №1-2. - P. 121-127.
    4. Vongchan P., Sajomsang W., Subyen D., Kongtawelerta P. Anticoagulant activity of a sulfated chitosan // Carbohydrate Research. -2002. - V.337. - №3. - P.1233-1236.
    5. Ilium L. Chitosan and its use as a pharmaceutical excipient // Pharmaceutical Pesearch. - 1998. - V.15. - №9. - P. 1326-1331.
    6. Furda I. Multifunctional fat absorption and blood cholesterol reducing formulation comprising chitosan. US Patent 5736532, 1998.
    7. Sumiyoshi M., Kimura Y. Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice // J. Pharm. Pharmacol. -2006. - V.58. - №2. - P.201-207.
    8. Ni Mhurchu C, Dunshea-Mooij C.A., Bennett D., Rodgers A. Chitosan for overweight or obesity // Cochrane Database Syst. Rev. - 2005. - V.20. - №3. - P.93-99.
    9. Rhoades J., Roller S. Antimicrobial actions of degraded and native chitosan against spoilage organisms in laboratory media and foods // Applied and environmental microbiology. - 2000. - V.66. - №1. - P.80-86.
    10. Gil G., del Monaco S., Cerrutti P., Galvagno M. Selective antimicrobial activity of chitosan on beer spoilage bacteria and brewing yeasts // Biotechnol Lett. - 2004. - V.26. - №7.
      - P.569-574.
    11. Tsai G.J., Tsai M.T., Lee J.M., Zhong M.Z. Effects of chitosan and a low-molecular-weight chitosan on Bacillus cereus and application in the preservation of

    119

    cooked rice. // J. Food Prot. - 2006. - V.69. - №9. - P.2168-2175.

    1. Богданов В.Д., Сафронова T.M. Структурообразователи и рыбные композиции. М.: ВНИРО, 1993. - 177с.
    2. Сафронова Т.М. Применение хитозана в производстве пищевых продуктов приведено в «Хитин и хитозан. Получение, свойства и применение» / Под. ред. Скрябина К.Г., Вихоревой Г.А., Варламова В.П. -М: Наука, 2002. - С. 346-359.
    3. Metso S., Ylitalo R., Nikkila M., Wuolijoki E., Ylitalo P., Lehtimaki T. The effect of long-term microcrystalline chitosan therapy on plasma lipids and glucose concentrations in subjects with increased plasma total cholesterol: a randomised placebo-controlled double-blind crossover trial in healthy men and women // Eur. J. Clin. Pharmacol. - 2003. - V.59. - №10. - P.741-746.
    4. Албулов А.И., Самуйленко А.Я., Фролова M.A. «Хитин и хитозан. Получение, свойства и применение» / Под. ред. Скрябина К.Г., Вихоревой Г.А., Варламова В.П. - М: Наука, 2002. - С. 360-363.
    5. Gain В. Natural products gain flavor // Chemical week. - 1996. - V.158. -№48. - P.35-36.
    6. Zechendorf B. Sustainable development: how can biotechnology contribute? // Trends in Biotechnology. - 1999. - V.I7. - №6. - P.219-225.
    7. Davidson K. «Plant growth regulators derived from chitin». US Patent 4964894,2006.
    8. Nemtsev S.V., Il'ina A.V., Varlamov V.P., Ozeretskovskaya O.L., Vasyukova N.I., Chirkov S.N., Skryabin K.G. Stimulation of plant growth and induction of potato resistance to diseases by low molecular weight chitosan // Bulletin of the Polish Academy of Sciences. - 2003. - V.51. - №3. - P.243-249.
    9. Surguchova N.A., Varitsev Yu.A., Chirkov S.N. The inhibition of systemic viral infections in potato and tomato plants by chitosan treatment // J.
      Russ. Phytopathol. Soc. - 2000. - V.47. - №3. - P.59-62.
    10. Pospieszny H. Antiviroid activity of chitosan // Crop Protection. - 1997. -V.16.-№2.-P.105-106.

    120

    1. Васюкова Н.И., Зиновьева СВ., Ильинская Л.И., Переход Е.А., Чаленко Г.И., Герасимова Н.Г., Ильина А.В., Варламов В.П., Озерецковская О.Л. Модулирование болезнеустойчивости растений с помощью низкомолекулярного хитозана // Прикладная биохимия и микробиология. - 2001. - Т.З7. - №1. - С. 115-122.
    2. Rhazi М, Desbrieres J., Tolaimate A., Rinaudo М., Vottero P., Alagui A., Meray M. Influence of the nature of the metal ions on the complexation with chitosan. Application to the treatment of liquid waste // European Polymer Journal. - 2002. - V.38. - №8. - P.1523-1530.
    3. Немцев СВ. Комплексная технология хитина и хитозана из панциря ракообразных. М.: ВНИРО, 2006. - 134с.
    4. Vincent J.V. Arthropod cuticle: a natural composite shell system // Composites: Part A. - 2002. - V.33. - №10. - P.1311-1315.
    5. Stankiewicz В., Mastalerz M., Hof С J., Bierstedt A., Flannery M.B., Derek E. G., Evershed B. Biodegradation of the chitin-protein complex in crustacean cuticle // Org. Geochem. - 1998. - V.28. -№2. - P.67-76.
    6. Антарктический криль: Справочник. / Под. ред. В.М. Быковой. - М: ВНИРО, 2001.-207с.
    7. Мезенова О.Я., Лысова А.С., Григорьева Е.В. Гаммарус балтийский -потенциальный источник получения хитина и хитозана // Мат. VII Международной конф. «Современные перспективы в исследовании хитина и хитозана». - М.: ВНИРО, 2003. - С.32-33.
    8. Феофилова Е.П. Применение хитозана в производстве пищевых продуктов приведено в «Хитин и хитозан. Получение, свойства и применение» / Под. ред. Скрябина К.Г., Вихоревой Г.А., Варламова В.П. -М: Наука, 2002. - С.91-110.
    9. Lipke P. N., Ovalle R. Cell Wall Architecture in Yeast: New Structure and New Challenges // Journal of Bacteriology.
      - 1998. - V.180. - №15. - P.3735-3740.
    10. Унрод   В.И.,   Солодовник   T.B.    Хитин-    и    хитозансодержащие

    121

    комплексы из мицелиальных грибов: получение, свойства, применение // Биополимеры и клетка. - 2001. - Т. 17. - №6. - С.526-533.

    1. Тесленко А.Я., Воеводина И.Н., Галкин А.В., Львова Е.Б., Никифорова Т.А., Николаев СВ., Михайлов Б.В., Козлов В.П. Патент № 2043995. Россия, 1995.
    2. Pochanavanich P., Suntornsuk W. Fungal chitosan production and its characterization // Letters in Applied Microbiology. - 2002. - V.35. - №1. -P.17-21.
    3. Hamodrakas S.J., Willis J.H., Iconomidou V.A. A structural model of the chitin-binding domain of cuticle proteins // Insect biochemistry and molecular biology. - 2002. - V.32. - №11. - P.1577-1583.
    4. Tellam R.L., Eisemann С Chitin is only a minor component of the peritrophic matrix from larvae of Lucilia cuprina // Insect biochemistry and molecular biology. - 2000. - V.30. - №12. - P.l 189-1201.
    5. Шовен P. Физиология насекомых. Перевод с фран. В.В. Хвостовой / Под. ред. Е.Н. Павловского.-М: Ин. Лит-ры, 1953. - 494с.
    6. Тыщенко В.П. Физиология насекомых. Уч. Пособие.-М: Высш.шк, 1986.-303с.
    7. Харсун А.И. Биохимия насекомых. Кишинев: Карта, 1976. - С.170-181.
    8. Курченко В.П., Кукулянская Т.А., Новиков Д.А. Физико-химические и биологические свойства меланиновых пигментов // Мат. VII Международной конф. «Современные перспективы в исследовании хитина и хитозана». - М.: ВНИРО, 2003. - С.23-31.
    9. Бриттон Г. Биохимия природных пигментов. М: Мир, 1986. - 436с.
    10. Riley Р.А. Melanin // Int. Biochem. Cell Biol. - 1997. - V.29. - №11. -P.1235-1239.
    11. Kayser H., Palivan C.G. Stable free radicals in insect cuticles: electron spin resonance spectroscopy reveals differences between melanization and sclerotization // Arch. Biochem. Biophys. - 2006. - V.453. - №2. - P. 179-187.
    12. Бышнева  Л.Н.,  Сенчук  В.В.   Влияние   меланинов   на  перекисное

    122

    окисление липидов // Прикладная биохимия и микробиология. - 2001. -Т.37.-№1.-С.105-109.

    1. Барабой В.А. Структура, биосинтез меланинов, их биологическая роль и перспективы применения // Успехи современной биологии. - 2001. -Т.121.-№1.-С.36-46.
    2. Горбунова Н.П. Альгология: Уч. пособие для вузов по спец. «Ботаника» - М.: Высш.шк., 1991. - 256с.
    3. Николаев В.А., Харвуд Д.М. Морфология, таксономия и система классификации центрических диатомовых водорослей. - СПб.: Наука, 2002.-118с.
    4. Ерофеев Н.С. Основы биологии дробянок, водорослей, грибов и лишайников: Уч. пособие. - Саранск: Из-во Мордов. ун-та, 2001. - 172с.
    5. Place A.R. The biochemical basis and ecological significance of chitin digestion // In: Chitin Enzymology / Ed. R.A.A. Muzzarelli. Atec, Italy, 1996. -V.2. - P.39-54.
    6. Немцев СВ., Зуева О.Ю., Исмаилов В.Я., Варламов В.П. Кутикула жуков станет новым источником хитина и хитозана // Мат. VII конф. «Современные перспективы в исследовании хитина и хитозана».-М: ВНИРО, 2003. - С.36-42.
    7. Немцев СВ., Зуева О.Ю., Хисматуллин Р.Г., Хисматуллин М.Р., Лариков В.В., Варламов В.П. Хитозан из подмора пчел - новый продукт пчел // Пчеловодство. - 2001. - №5. - С.50-51.
    8. Немцев СВ., Зуева О.Ю., Хисматуллин М.Р., Албулов А.И., Варламов В.П. Получение хитина и хитозана из медоносных пчел // Прикладная биохимия и микробиология. - 2004. - Т.40. - №1. - С.46-50.
    9. Быков В.П., Быкова В.М., Головкова Г. Н. Хитин и хитозан из биомассы личинок мух. // Тез. 4-ой Всерос. конф. "Производство и применение хитина и хитозана". - М: ВНИРО, 1995.- С.10-12.
    10. Шыш СИ., Винокурова Г.В. Способ получения хитина и способ получения хитозана. Патент № 2139887. Россия, 1996.

    123

    1. Кузин Б.А., Бабиевский К.К., Прохоренко Г.К., Кузин А.Б. Способ получения хитозана. Патент № 2067588. Россия, 1996.
    2. Struszczyk М.Н., Hahlweg R., Peter M.G. Comparative analysis of chitosans from Insects and Crustacean // In: Advan.Chitin Sci. / Ed. M.G. Peter, A. Domard, R.A.A. Muzzarelli. Potsdam. Germany, 2000. - V4. - P.40-49.
    3. Lamberty M., Ades S., Uttenweiler-Joseph S., Brookhart G., Bushey D., Hoffmann J.A., Bulet P. Insect immunity. Isolation from the lepidopteran Heliothis virescens of a novel insect defensin with potent antifungal activity // J. Biol. Chem. - 1999. - V.274. - №14. - P.9320-9326.
    4. Boman H.G. Peptide antibiotics: holy or heretic grails of innate immunity? // Scand. J Immunol. - 1996. - V.43. - №5. - P.475-482.
    5. Holak T.A., Engstrom A., Kraulis P.J., Lindeberg G. The solution conformation of the antibacterial peptide cecropin A: a nuclear magnetic resonance and dynamical simulated annealing study // Biochemistry. - 1988. - V.27. - №20. -P.7620-7629.
    6. Boman H.G., Hultmark D. Cell-free immunity in insects // Annu. Rev. Microbiol. -1987. - V.41. - P.103-126.
    7. Boman H.G., Faye I., Gudmundsson G.H., Lee J.Y., Lidholm D.A. Cell-free immunity in Cecropia. A model system for antibacterial proteins // Eur. J. Biochem. -1991. - V.201. -№1. - P.23-31.
    8. Marchini D.,Giordano P.C., Amons R., Bernini L.F., Dallai R. Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata II Insect Biochem Mol Biol. -1993. - V.23. - №5. - P.591-598.
    9. Vizioli J., Salzet M. Antimicrobial peptides versus parasitic infections? // Trends Parasitol. - 2002. - V.18. - №11. - P.475-486.
    10. Cociancich S., Dupont A., Hegy G., Lanot R. Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus II Biochem. J. -1994. - V.300. - №2. - P.567-575.
    11. Fehlbaum P., Bulet P., Michaut L., Lagueux M., Broekaert W.F. Insect

    124

    immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides // J Biol. Chem. -1994. - V.269. -№.52. - P.33159-33163.

    1. Fehlbaum P., Bulet P. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides // Proc. Natl. Acad. Sci. USA,-1996. - V.93. - №3. - P.1221-1225.
    2. Bulet P., Stocklin R. Insect antimicrobial peptides: structures, properties and gene regulation // Protein Pept. Lett. - 2005. - V.12. - №1. - P.3-11.
    3. Hultmark D. Insect immunology. Ancient relationships // Nature; - 1994. -V.367.- №6459. -P.l 16-127.
    4. Otvos L. Antibacterial peptides isolated from insects // J. Pept. Sci. -2000.-V.6.-№10.-P.497-511.
    5. Jovanovic D., Skodric-Trifunovic V., Markovic-Denic L., Stevic R. Clinical and epidemiological evaluation of tuberculosis // Int. J Tuberc. Lung Dis. - 2007. -V.ll.-№6.-P.647-651.
    6. Goicoechea H.C., Olivieri A.C. Simultaneous determination of rifampicin, isoniazid and pyrazinamide in tablet preparations by multivariate spectrophotometric calibration // J. Pharm. Biomedical Analysis. - 1999. - V.20. -№4.-P.681-686.
    7. Andries K., Verhasselt P, Guillemont J, Gohlmann HW. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis II Science. - 2005. -V.307.-№5707.-P.223-227.
    8. Jarosz J. Simultaneous induction of protective immunity and selective synthesis of hemolymph lysozyme protein in larvae of Galleria mellonella II Biol. Zbl. - 1979. - V.98. - №4 - P.459-471.
    9. Dunphy G.B. Virulence of Candida albicans mytants toward larval Galleria mellonella// Can. J. Microbiol. - 2003. - V.49. - №8. - P.514-524.
    10. Гилмур Д. Метаболизм насекомых. М: Мир, 1968. - 229с.
    11. Хоменко А.Г., Авербах М.М., Александрова А.В. Туберкулез органов дыхания. М.: Медицина. 1998. - 189с.

    125

    1. Анненков Г.А. «Липазная концепция» лечения туберкулеза человека. М.: Адамант.- 2006. - 52с.
    2. Mankiewicz Е. The action of lipidolytic enzymes of larvae of Galleria mellonella on virulent Mycobacterium tuberculosis II Canad. J. Med. Sciences. -1952.-V.76.-P.295-329.
    3. Wlodawer P., Branska J. Lipolytic activity of the fat body of the waxmoth larvae // Acta Bioch. Polonica. 1965.-V.12.-№l.-P.23-47.
    4. Wlodawer P., Lagwinska E., Baranska J. Esterification of fatty acids in the wax moth haemolymph and its possible role in lipid transport. // J. Insect Physiol. 1966.-V.12.-№5.-P.547-560.
    5. Анненков Г.А., Клепиков H.H., Мартынова Л.П., Пузанов В.А. О возможности применения природных липаз и эстераз для ингибирования MycobacteriumtuberculosisIIПроблемы туберкулеза и болезней легких. -2004. - №6. - С.52-56.
    6. Raetz C.R., Reynolds СМ., Trent M.S., Bishop R.E. Lipid A Modification Systems in Gram-negative bacteria. // Annu. Rev. Biochem. - 2007. - V.76. -P.295-329.
    7. Jain M., Petzold С J., Schelle M.W., Leavell M.D., Mougous J.D., Bertozzi C.R., Leary J.A., Cox J.S. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. // Proc. Natl. Acad. Sci. U S A. - 2007. - V.104. - №12. - P.5133-5138.
    8. Ehrt S, Schnappinger D. Mycobacterium tuberculosis virulence: lipids inside and out // Nat. Med. - 2007. - V.13. - №.3. - P.284-295.
    9. Lim S.H., Hudson S.M. Review of chitosan and its derivatives as antimicrobial agents and their uses as textile chemicals // J. Macromol. Sci. - 2003. -V.43. - №2. - P.223-269.
    10. Liu X.F., Guan Y.L., Yang D.Z., Li Z., Yao K.D. Antibacterial action of chitosan and carboxymethylated chitosan // J. Appl. Polym. Sci. - 2001. - V.79. - №9. -P. 1324-1335.
    11. Smith J., Wood E., Dornish M. Effect of chitosan on epithelial cell tight

    126

    junctions // Pharmaceutical Research. - 2004. - V.21. - №1. - P.43-49.

    1. Muzzarelli R.A.A., Muzzarelli C, Tarsi R., Miliani M., Gabbanelli F.,Cartolari M. Fungistatic activity of modified chitosans against Saprolegnia parasitica II Biomacromolecules. - 2001. - V.2. - № 1. - P.l65-169.
    2. Senel S., Ikinci G., Kas S., Yousefi-Rad A., Sargon M.F., Hincal A.A. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery // Int. J. Pharm. - 2000. - V.193. - №2. - P.197-203.
    3. Sosa M.A., Fazely F., Koch J.A., Vercellotti S.V., Ruprecht R.M. N-carboxymethylchitosan-N, O-sulfate as an anti-HIV-1 agent // Biochem. Biophys.Res. Commun. -1991. - V. 174. - №2. - P.489-496.
    4. Roller S., Covill N. The antifungal properties of chitosan in laboratory media and apple juice // Int. J. Food. Microbiol. -1999. - V.47. - №1-2. - P.67-77.
    5. Rabea E.I., Badawy M. E.-T., Stevens C.V., Smagghe G., Steurbaut W. Chitosan as antimicrobial agent: applications and mode of action // Biomacromolecules. - 2003. - V.4. - №6. - P.1457-1465.
    6. Chung Y.C., Wang H.L., Chen Y.M., Li S.L. Effect of abiotic factors on the antibacterial activity of chitosan against waterborne pathogens // Bioresour. Technol. - 2003. - V.88. -№3. - P. 179-184.
    7. No H.K., Park N.Y., Lee S.H., Meyers S.P. Antibacterial activity of chitosans and chitosan oligomers with different molecular weights // Int. J. Food. Microbiol.-2002.-V.74.-№l-2.-P.65-72.

    115.Alsarra I.A., Betigeri S.S., Zhang H., Evans B.A., Neau S.H. Molecular weight and degree of deacetylation effects on lipase-loaded chitosan bead characteristics // Biomaterials. - 2002. - V.23. - №17. - P.3637-3644.

    1. Sano H., Shibasaki K., Matsukubo Т., Takaesu Y. Effect of molecular mass and degree of deacetylation of chitosan on adsorption of Streptococcus sobrinus 6715 to saliva treated hydroxyapatite // Bull. Tokyo Dent. Coll. - 2002. - V.43. - №2. -P.75-82.
    2. Kumar A.B.V., Varadaraj M.C., Lalitha R.G., Tharanathan R.N. Low molecular weight chitosans: preparation with the aid of papain and characterization //

    127

    Biochim. Biophys. Acta. - 2004. - V.1670. - №1. - P.137-146.

    1. Feofilova E.P., Mar'in A.P., Tereshina V.M., Nemsev D.M., Kozlov V.P. Role of components of cell walls in metal uptake by Aspergillus niger II Res. Environ. Biotech.- 2000. - V.3.-P.61-69
    2. Choi B.-K., Kim K.-Y., Yoo Y.-J., Oh S.-J., Choi J.-H., Kim C.-Y. In vitro antimicrobial activity of a chitooligosacharide mixture against Actitinomyces emcomitans and Streptococcus mutants II Int. J. Antimicrob. Agents. - 2001. -V.18.-№6.-P.553-557.
    3. Cuero R.G. Antimicrobial action of exogenous chitosan // EXS. - 1999. -V.87.-P.315-333.
    4. Sorlier P., Denuziere A., Viton C, Domard A. Relation between the degree of acetylation and electrostatic properties of chitin and chitosan // Biomacromolecules. - 2001. - V.2. - № 3. - P.765-772.
    5. Tsai G.-J., Hwang S.-P. In vitro and in vivo antibacterial activity of shrimp chitosan against some intestinal bacteria // Fisheries Sci. - 2004. - V.70. - № 5 - P.675-681.
    6. Kim Y.H., Gihm S.H., Park C.R., Lee K.Y., Kim T.W., Kwon I.C., Chung H, Jeong S.Y. Structural characteristics of size-controlled selfaggragates of deoxycholic acid-modified chitosan and their application as a DNA delivery carrier // Bioconjug. Chem. - 2001. - V.12. - №6. - P.932-938.
    7. MacLaughlin F.C., Mumper R.J., Wang J., Tagliaferri J.M., Gill I.,Hinchcliffe M., Rolland A.P. Chitosan and depolimerized chitosan oligomers as condensing carriers for in vivo plasmid delivery // J. Control. Release. - 1998. -V.56.-№l-3.-P.259-272.
    8. Hu S.-G., Jou C.-H., Yang M.C. Protein adsorption, fibroblast activity andantibacterial properties of poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) grafted with chitosan and chitooligisaccharide after immobilized with hyaluronic acid // Biomaterials. - 2003. - V.24. - №16 - P.2685-2693.
    9. Tang Z.H., Hou C.L., Chen Q.Q. Experimental study on bacteriostatic of chitosan and sodium hyaluronate // Zhongguo. Xiu. Fu. Chong. Jian. Wai. Ke. Za.

    128

    Zhi. - 2002. - V.l 6. - №4. - P.259-261.

    1. Felt O., Carrel A., Baehni P., Buri P., Gurny R. Chitosan as tear substitute: a wetting agent endowed with antimicrobial efficacy // J. Ocul. Pharmacol. Ther. -2000. - V.16. - №3. - P.261-270.
    2. Червинец B.M., Бондаренко B.M., Виноградов В.Ф., Чернин В.В., Базлов С.Н., Комаров Б.А., Албулов А.И., Смоленская Л.В. Антибактериальная и антиадгезивная активность хитозана // Сборник научных трудов «Нетрадиционные природные ресурсы, инновационные технологии и продукты». - М: Москва, 2002. - С. 181-187.
    3. Герасименко Д.В., Авдеенко И.Д., Банникова Г.Е., Зуева О.Ю., Варламов В.П. Антибактериальная активность водорастворимых низкомолекулярных хитозанов в отношении различных микроорганизмов // Прикладная биохимия и микробиология. - 2004. - Т.40. - №3. - С.ЗО 1-306.
    4. Jia Z., Shen D., Xu W. Synthesis and antibacterial activities of quaternary ammonium salt of chitosan // Carbohydr. Res. - 2001. - V.333. - №1. - P. 1-6.
    5. Meyer H., Butte W., Schlaak M. Influence of chitosan on bacterial growth// Chitosan in Pharmacy and Chemistry. Eds.: R.A.A. Muzzarelli, С Muzzarelli. Atec.Italy.2002.-P. 157-163.
    6. Myoung H. S., Choi M.H., Jo D.H., Park Y.H. Binding mechanism of low molecular weight chitosan to bacterial celles // Advances in chitin science. Proceedings of the 5th Asia Pacific Chitin and Chitosan Symposium amp; Exhibition, Bangkok, Thailand. 2002. - P.242-245.
    7. Vaara M. Agents that increase the permeability of the outer membrane // Microbiol. Rev. -1992. - V.56. - № 3. - P.395-411.
    8. Savard Т., Beaulieu C, Boucher Г, Champagne C.P. Antimicrobial action of hydrolyzed chitosan against spoilage yeasts and lactic acid bacteria of fermented vegetables //J. Food Prot. - 2002. - V.65. - №5. - P.828-833.
    9. Kaambre Т., Tougu V., Kaambre P., Vija H., Sikk P. Hydrolysis of emulsified mixtures of triacylglycerols by pancreatic lipase // Biochim Biophys Acta. -1999. - V.12. - №1. - P. 97-106.

    129

    1. Hostacka A. Characteristics of strains of Acinetobacter spp. after culture in various media //.Epidemiol Mikrobiol Imunol. - 2003. - V.52. - №2. - P.72-75.
    2. Wang Т., Chen T. Lipase prodaction by Acinetobacter radioresistens in a batch fill-and-draw culture // Appl. Biochem. Biotechnol. - 2005. - V.73. - №2-3. -P. 183-194.
    3. Dupuis C, Corre С Lipase and Esterase Activities of Propionibacterium freudenreichii subsp. Freudenreichii II Appl Environ Microbiol. - 1993. - V.59. -№12.-P.4004-4009.
    4. Luo Y., Zheng Y., Jiang Z., Ma Y., Wei D. A novel psychrophilic lipase from Pseudomonas fluorescens with unique property in chiral resolution and biodiesel production via transesterification // Appl Microbiol Biotechnol. - 2006. - V.73. -№2. - P.349-355.
    5. Allen D.K., Tao B.Y. Kinetic characterization of enhanced lipase activity on oil bodies // Bioprocess Biosyst Eng. - 2007. - V.30. - №2. - P. 1344-1350.
    6. Hasan F., Shah A., Hameed A. Purification and characterization of a mesophilic lipase from Bacillus subtilis FH5 stable at high temperature and pH // Acta Biol. Hung. - 2007. - V.58. - №1. - P.l 15-132.
    7. Shu Z.Y., Yang J.K., Yan J.K. Purification and characterization of a lipase from Aspergillus niger F044 // Sheng Wu Gong Cheng Xue Bao. - 2007. - V.23. -№1.-P.96-100.
    8. Aloulou A, Rodriguez J A, Puccinelli D, Mouz N, Leclaire J, Leblond Y, Carriere F. Purification and biochemical characterization of the LIP2 lipase from Yarrowia lipolytica II Biochim. Biophys. Acta. - 2007. - V. 1771. - №2. - P.28-37.
    9. Nawani N, Khurana J, Kaur J. A thermostable lipolytic enzyme from a thermophilic Bacillus sp.: purification and characterization // Mol. Cell Biochem. -2006. -V.290.- №1-2. -P.17-22.
    10. Fujino S, Akiyama D, Akaboshi S, Fujita T, Watanabe Y, Tamai Y. Purification and characterization of phospholipase В from Candida utilis. II Biosci. Biotechnol. Biochem. - 2006. - V.70. - №2. - P.377-386.
    11. Sarda L, Desnuelle P. Action of pancreatic lipase on emulsified esters. //

    130

    Biochim.Biophys. Acta. -1993. - V.37. - №7. - P. 1608-1633.

    1. Brady L., Brzozowski A.M., Derewenda L.S., Dodson E., Dodson G.A serine protease triad forms the catalytic centre of a triacylglycerol lipase. // Nature. - 1990. - V.343. - №34. - P.767-770.
    2. Van Tilbeurgh H., Sarda L., Verger R., Cambillau C. Structure of the pancreatic lipase-procolipase complex. // Nature. - 1992. - V.359. - №6. - P. 159-162.
    3. Derewenda U., Brzozowski A.M., Lawson D.M., Derewenda Z.S. Catalysis at the Interface: The anatomy of a conformational change in a triglyceride lipase. //Biochemistry. - 1992. - V.31. - №5. - P.1532-1541.
    4. Brzozowski A.M., Derewenda U., Derewenda Z.S., Dodson G.G. A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. //Nature. - 1991. - V.351. - №6326. - P.491-494.
    5. Noble M.E., Cleasby A., Johnson L.N., Frenken L.G.J., Egmond M.R. The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate. // FEBS Lett. - 1993. - V.331. -№l-2.-P.123-128.
    6. Uppenberg J., Patkar S., Bergfors Т., Jones T.A. Crystallization and preliminary X-ray studies of lipase from Candida Antarctica II Mol. Biol. - 1994. - V.235. - №2. - P.790-792.
    7. Jaeger K.E. Ransac S., Koch H.B., Ferrato F. Dijkstra B.W. Topological characterization and modeling of the 3D structure of lipase from Pseudomonas aeruginosa II FEBS Lett. -1993. - V.332. - №1-2. - P. 143-149.
    8. Nardini M., Lang D.A., Liebeton K., Jaeger K.E., Dijkstr B.W. Crystal structure of Pseudomonas aeruginosa lipase in the open conformation. // J. Biol. Chem. - 2000. - V.275. -№40. - P.31219-31225.
    9. Hjorth A., Carriere F., Cudrey C, Woldike H., Boel E., Lawson D.M., Verger R. A structural domain (the lid) found in pancreatic lipases is absent in the guinea pig (phospho) lipase // Biochemistry. - 1993. - V.32. -№18.-P.4702-4707.

    131

    1. Jennens M.L., Lowe M.E. A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding // J. Biol., Chem. - 1994. - V.269. - №41. - P.25470-25474.
    2. Mensink R.P., Katan M.B. Effect of dietary trans fatty acids on the high-density and low-density lipoprotein cholesterol levels in healthy subjects // Eng. J. Merd. -1990. - V.323. - №7. - P.439-445.
    3. Rousseau D., Marangoni A.G. Tailoring the textural attributes of butter fat/canola oil blends via Rhizopus arrhizus lipase-calalyzed iterification. I. Compositional modification // J. Agric. Food. Chem. - 1998. - V.46. - №12. -P.2368-2374.
    4. Forssell P., Kervinen R., Lappi M., Linko P. Effect of enzymatic iterefication on the melting point of tallow-rapeseed oil (LEAR) mixture // J. Am. Oil. Chem. Soc. -1992. - V.69. - №1. - P. 126-129.
    5. Basheer S., Mogi K., Nakajima M. Interesterification kinetics of triglycerides and fatty acids with modified lipase in n-hexane // J.Am. Oil. Chem. Soc. -1995. - V.72. - №3. - P.511-518.
    6. Mohamed H.M., Bloomer S., Hammadi K. Modification of fats by lipase interesterification. Changes in triglyceride structure // Fat. Sci. Technol. - 1993. -V.95.-№2.-P.428-431.
    7. Bracco U. Effect of triglyceride structure on fat absorption // J. Am. Clin. Nutr. -1994. - V.60. - №6. - P.1002-1009.
    8. Kennedy J.P. Srtructured lipids: fats for the future // Food Technol. - 1991. -V.45. - №2. - P.76-83.
    9. Schmid U. Highly selective synthesis of l,3-olcoyl-2 palmitoylglycerol by lipase catalysis // Biotechnol. Bioeng. - 1999. - V.64. - №6. - P.678-684.
    10. Jandacek R.J., Whiteside J.A., Holcombe B.N. The rapid hydrolysis and efficient absorption of triglycerides with octanoic acid in the 1-position and 3-position and long-chain fatty acid in the 2-positon. // J.Am. Clin. Nutr. - 1987. -V.45.-№5.-P.940-945.
    11. Quinlan P., Moore S. Modification of triglycerides by lipases: process

    132

    technology and its application to the production of nutritionally improved fats // INFORM - 1990. - V.4. - P.580-585.

    1. Haraldsson G.G. Using biotechnology to modify marine lipids // INFORM. -1992.-V.3.-P.626-629.
    2. Sridhar R., Lakshminarayana G., Incorporation of eicosapentaenoic and docosahexacnoic acids into groundnut oil by lipase-catalyzed ester interchange // J.Am. Oil. Chem. Soc. - 1992. - V.69. -№11.- P. 1041-1044.
    3. Diks R.M.M., Lee M.J. Production of very low saturate oil based on the specificity of Geotrichum candidum lipase // J. Am. Oil. Chem. Soc. - 1999. -V.76. - P.455-462.
    4. Valfson. E.N. Lipases: their structure, biochemistry and application. Cambridge: Cambridge University Press. 1994, P. 271-286.
    5. Чешкова A.B., Лебедева В.И., Мельников Б.Н. Исследование деструкции воскообразных веществ хлопка под действием ферментов // Химия и химическая технология. -1995.- Т.38. - Вып. 4-5. - с.91-93.
    6. Tanaka Y., Hirano J%Funada Т. Concentration of docosahexaenoic acid by gliceride by hydrolysis of fish oil with Candida cylindracea lipase // J. Am. Oil. Chem. Soc. -1992. - V.69. - P.1210-1214.
    7. Shimada Y., Sugihaira A., Nakano H., Xuramoto Т., Nagao T. Purification of docosahexaenoic acid by selective esterification of fatty acids from tuna oil with Rhizopus delemar lipase // J. Am. Oil. Chem. Soc. - 1997. - V.74. - P.97-101.
    8. Bellot J., Choisnard L., Castillo E., Marty A. Combining solvent engineering and thermodynamic modeling to enhance selectivity during monoglyceride synthesis by lipase-catalyzed esterification // Enzyme Microb. Technol. - 2001. - V.28. - №11. - P.362-369.
    9. Monteiro J.B., Nascimento M.G., Ninow J.L. Lipase-catalyzed synthesis of monoacylglycerol in homogeneous system // Biotechnol. Lett. - 2003. - V.25. -№8.-P.641-644.
    10. Bomscheuer U., Stamatis H., Xenakis A.T., Yamane T. A comparison of different   strategies   for   lipase-catalyzed   synthesis   of partial   glycerides   //

    133

    Biotechnol. Lett. -1994. - V.16. - P.679-702.

    1. Van Ее J.H., Misset O., Baas E.J. Enzymes in detergency. New York: Marcel Dekker press. 1997. - P.93-106.
    2. Boel R., Christensen T. Novo Nordisk AS, USA Patent 5536661,1996
    3. Fujita Y., Awaji H., Matsukura M., Hata K., Shimoto H. Recent advances in enzymic pitch control // Tappi J. - 1992. - V.75. - P. 117-122.
    4. Lankisch P.G. Enzyme treatment of exocrine pancreatic insufficiency in chronic pancreatitis // Digestion. -1993. - V.54. - №2. - P.21-29.
    5. Wickler-Planquart C, Canaan S., Riviere M., Dupuis L. Expression in insect cells and purification of a catalytically active recombinant human gastric lipase // Protein Eng. - 1996.-V.9. - №12. - P.1225-1232.
    6. Suzuki A., Mizumoto A., Sarr M.G., Dimagno E.P. Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea. // Gastroenterology. - 1997. - V.l 12. №6. - P.2048-2055.
    7. Zhi J., Melia G., Kosstwardy S.G., Min B. The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburidc in healthy volunteers // J. Clin. Pharmacol. - 1995. - V.35. - №5. - P.521-525.
    8. Schwizer W., Asal K., Kreiss C, Mettraux C, Burovicka J. Role of lipase in the regulation of upper gastrointestinal function in humans // Am. J. Physiol. -

    1997.              - V.273. - №3. - P.612-620.

    185.              Hildebrand P., Petrig C, Burckhardt P., Ketterer S. Hydrolysis of dietary fat

    by pancreatic lipase stimulates cholecystokinin release // Gastroenterology. -

    1998.              - V.l 14. - №i.. p.l 123-1129.

    1. Finer N. Drug treatments for obesity // Lancet. - 2007. - V.6. - №369. - P.71-77.
    2. Souri E., Jalalizadeh H., Kebriaee-Zadeh A., Zadehvakili B. HPLC analysis of orlistat and its application to drug quality control studies // Chem. Pharm. Bull. -2007.-V.55.-№2.-P.251-254.
    3. Singh A, Sarkar SR, Gaber LW, Perazella MA. Acute oxalate nephropathy associated with orlistat, a gastrointestinal lipase inhibitor. // Am. J, Kidney Dis. -

    134

    2007.-V.49.-№1.-153-157.

    1. Padwal R.S., Majumdar S.R. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. // Lancet. - 2007. - V.6. - №369. - P.71-77.
    2. Gao C, Whitcombe M.J., Vulfson E.N. Enzymatic synthesis of dimeric and trimeric sugar-fatty acid esters // Enzym. Microb. Technol. - 1999. - V.25. -№2. - P.264-270.
    3. Riva S. Enzymatic modification of sugar moieties of natural glycosides // J. Mol. Cat. B; Enzymatic. - 2002. - V. 19. - №3. - P.43-54
    4. Colombo D., Ronchetii F., Seala A., Toma L. Bioactive glycoglycerolipid analogues: an expeditious enzymatic approach to mono- and diesters of 2-0-(3-D-galactosylglycerol // Tetrahedron: Asymmetry. - 1998. - V.9. - P.2113-2119.
    5. Nishino H., Colombo D., Ronchetii F., Scala A., Toma L. Chemoenzymatic synthesis and antitumor promoting activity of 6- and 3-esters of 2-0- P -D-Glycosylglycerol // Bioorg. Med. Chem. - 1999. - V.7. - P. 1867-1871.
    6. Bousquet M.P., Willemot R.M., Monsan P., Boures E. Lipase-catalyzed a-butylglucoside lactate synthesis in organic solvent for dermo-cosmetic application // J. Biotechnol. -1999. - V.68. - P.61-69.
    7. Manjon A., lborra J.L., Arocas A. Short chain flavour ester synthesis by immobilized lipase in organic media // Biotechnol. Lett. - 1991. - V.13. - №3 -P.339-344.
    8. Claon P.A., Akoh C.C. Effect of reaction parameters on sp435 lipase-catalyzed synthesis of citronellyl acetate in organic solvent // Enzyme Microb. Technol. - 1994. - V.16. - P.835-838.
    9. Buchalska E., Plenkicwiez J. Synthesis of optically active aminooxy alcohols. // J. Mol.Cat. В.: Enzymatic.-2001.-V.l 1. - №3. - P.255-263.
    10. Hegemann K., Schimanski H., Haweler U., Haufe G. Selectivity of С rugosa lipase in. simultaneous separation of skeletal isomers, dcsymmetrization, and kinetic racemate cleavage of 9 oxobicyclononanediols // Telrahedron Lett. - 2003.

    135

    - V.44. - Р.2225-2229.

    1. Ghanem A., Aboul-Enein H.Y. Application of lipase in kinetic resolutiom of racemates // Chirality. - 2005. - V. 17. - № 1. - P. 1-15.
    2. Dordick J.S. Enzymatic and chemoenzymatic approaches to polymer synthesis //Trends. Biotechnol. - 1992. - V.10. - P.287-293.
    3. Martin B.D., Ampofo S.A., Linhardt R.J., Dordick F.S. Biocatalytic synthesis of sugar containing poly(acrylate)-based hydrogeles // Macromolecules. -1992.-V.25.-P.7081-7085.
    4. Ильина A.B., Татаринова Н.Ю., Тихонов B.E., Варламов В.П. // Прикл. биохимия и микробиология. - 2000. - Т.36. - №2. - С. 173-177.
    5. Ilyina A.V., Tatarinova N.Yu., Varlamov V.P. The preparation of low-molecular-weight chitosan using chitinolytic complex from Streptomyces kurssanoviill Process Biochemistry. -1999. - V.34. - № 9. - P.875-878.
    6. Ильина A.B., Ткачева Ю.В., Варламов В.П. Деполимеризация высокомолекулярного хитозана ферментным препаратом Целловиридин Г20х. //Прикл. биохимия и микробиология. -2002. -Т.37. -№1. -С.132-135.
    7. Hung Т.Н., Giridhaz R., Chiou S.H., Wen-Teng W. Binary immobilization of Candida rugosa lipase on chitosan // J. Mol. Cat. B: Enzymatic. - 2003. - V.26. -№l.-P.69-78.
    8. Kido Y., Hiramoto S., Murao M., Horio Y., Miyazaki Т., Kodama Т., Nakabou Y. Epsilon-polylysine inhibits pancreatic lipase activity and suppresses postprandial hypertriacylglyceridemia in rats // J. Nutr. - 2003 - V.133. - №1. -P.1887-1891.
    9. Келети Т. Основы ферментативной кинетики. М.: Мир, 1994 - С.183-188.
    10. Yakovlev G.I., Mitkevich V.A., Struminskaya N. К., Varlamov V.P., Makarov A.A. Low molecular weigh chitosan is an efficient inhibitor of ribonucleases.// Biochem. Biophys. Res. Commun. - 2007 - V.357. - №3. -P.584-588.
    11. Spector T. Refinement of the coomassie blue method of protein quantitation.// Anal. Biochem. - 1978. - V.86. -№1. -P. 141-146.

    136

    1. Wang W., Bo S., Li S., Qin W. Determination of the Mark-Houwink equation for chitosans with different degree of deacetylation // Int. J. Biol. Macromol. -1991.-V.13.-№5.-P.281-285.
    2. Твердохлебова И.И. Конформация макромолекул (вискозиметрический метод оценки). - М.: Химия, 1981. - 281с.
    3. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. // Nature. - 1970. - V.227. -№7. - P.680-685.
    4. Быкова B.M., Немцев СВ. «Хитин и хитозан. Получение, свойства и применение» / Под. ред. Скрябина К.Г., Вихоревой Г.А., Варламова В.П.-М: Наука, 2002. - С.7-23.
    5. Percot A., Viton С, Domard A. Optimization of chitin extraction from shrimp shells // Biomacromolecules. - 2003. - V.4. - №1. - P. 12-18.
    6. Неклюдов А.Д., Иванкин A.H., Бердутина A.B. Свойства и применение белковых гидролизатов // Прикладная биохимия и микробиология. - 2000. -Т.36. - №5 - С.525-534.
    7. Лях СП. Микробный меланиногенез и его функции. М.: Наука. 1981. - 274с.
    8. Brooks R.E., Moore S.B. Alkaline hydrogen peroxide bleaching of cellulose // Cellulose. - 2000. - V.7. - №3. - P.263-286.
    9. Немцев СВ., Ильина СМ., Шинкарев СМ., Албулов А.И., Варламов В.П. Получение низкомолекулярного водорастворимого хитозана // Биотехнология.- 2001.- №6.-С37-42.
    10. Vachoud L., Zydowicz N., Domard A. Physicochemical behaviour of chitin gels // Carbohydrate Research. - 2000. - V.326. - №4. - P.295-304.
    11. Percot A., Chaussard G., Sorlier P., Shatz C, Montembault A., Viton C, Domard A. Overall considerations on the evolution of the study of chitosan properties // In:Advan.Chitin Sci. 9th ICCC / Ed. I. Boucher, K. Jamieson, A. Retnakaran. Montreal, 2003. - V.7. - P. 1-6.
    12. Chatelet C, Damour O., Domard A. Influence of the degree of acetylation on some biological properties of chitosan films // Biomaterials. - 2001. - V.22.

    137

    -№3.-Р.261-268.

    1. Chang К. L., Tsai G., Lee J., Fu W.-R. Heterogeneous N-deacetylation of chitin in alkaline solution // Carbohydrate Research. - 1997. - V.303. - №3. -P.327-332.
    2. Yang B.Y., Montgomery R. Degree of acetylation of heteropolysaccharides // Carbohydrate Research. - 2000. - V.323. - №4. -P.156-162.
    3. Стояченко И.А., Варламов В.П. Очистка и некоторые свойства хитиназ из StreptomyceskurssanoviiIIБиотехнология. - 1993. - №2. - С.29-36.
    4. Новиков В.Ю., Мухин В.А. Деполимеризация хитозана под действием ферментов гепатопакреаса камчатского краба Paralithodescamtschaticus// Прикладная биохимия и микробиология. - 2003. - Т.39. - №5. - С.530-535.
    5. Azarkan М., Moussaoui A., Wuytswinkel D., Dehon G., Looze Y. Fractionation and purification of the enzymes stored in the latex of Carica papaya II Journal of Chromatography B. - 2003. - V.790. - №1. - P.229-238.
    6. Ilina A.V., Varlamov V.P., Gabdrakmanova L.A., Yusupova D.V., Albulov A.I. Chitinolytic complex of Serratia marcescens as the tool in obtaining of low-molecular-weight water-soluble chitosan // In: Progr. on chemistry and application of chitin and its derivatives / Ed. H. Struszczyk. Poland, 2001.-V.7.-P. 57-63.
    7. Cox R.A., Cook G.M. Growth regulation in the mycobacterial cell // Curr. Mol. Med. - 2007. - V.7. - №3. - P.231-245.
    8. Chung Y.C., Su Y.P., Chen C.C., Jia G., Wang H.L., Wu J.C., Lin J.G.Relationship between antibacterial activity of chitosan and surface characteristics ofcell wall // Acta. Pharmacol. Sin. - 2004. - V.25. - №7.. p.932-939.
    9. Кочкина 3.M., Поспешный Г., Чирков С.Н. // Прикладная биохимия и микробиология . -1996. - Т.32. - №.2. - С.247-250.
    10. Akira I. // Chitin Handbook / Ed. R.A.A. Muzzarelli, M.G. Grottammare: Atec, 1997.-Р.103-108.
    11. Mak P., Chmiel D., Gasek G.J. Antibacterial peptides of the moth Galleria

    138

    mellonella // Acta Biohim. Pol. - 2001. - V.48. - №4. - P.l 191-1195.

    1. Hoffmann D., Hultmark D., Boman H.G. Insect immunity: Galleria mellonella and other Lepidoptera have cecropin-p9-like factors active against gram negative bacteria// Insect Biochem. -1981. - V.l 1. - №5. - P.537-548.
    2. Frobius A.C., Kanost M.R., Gotz P., Vilcinskas A. Isolation and characterization of novel inducible serine protease inhibitors from larval hemolymph of the greater wax moth Galleria mellonella // Eur. J. Biochem. - 2000. -V.267.-№7.-P.2046-2053.
    3. Arias M.A., Sanchez A.M., Alonso-Fernandez A., Garcia-Rio F. Atrial fibrillation, obesity, and obstructive sleep apnea // Arch. Intern. Med. - 2007. -V.23.-№167.-P.1552-1553.
    4. Sumiyoshi M., Kimura Y. Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice // J Pharm. Pharmacol. - 2006. -V.58.-№.2.-P.201-207.
    5. Ni Mhurchu C, Dunshea-Mooij C.A., Bennett D., Rodgers A. Chitosan for overweight or obesity // Cochrane Database Syst. Rev. - 2005. - V.20. - №3. -P.5563-5669.
    6. Kotsovolou S., Chiou A., Vergu R. Bis-2-oxo amide triacylglycerol analogues: a novel class of potent human gastric lipase inhibitors. II J. Org. Chem. - 2001. - V.66. - №3. - P.962-967.
    7. Zhao H.L., Kim Y.S. Determination of the kinetic properties of platycodin D for the inhibition of pancreatic lipase using a 1,2-diglyceride-based colorimetric assay. // Arch. Pharm. Res. - 2004. - V.27. - №3. - P.968-972.
    8. Han L., Kimura Y., Kawashima M. Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor // Int. J. Obes. Relat. Metab. Disord. - 2001. - V.25. -№3.-P.1459-1464.
    9. Eisenreich W., Kupfer E., Stohler P. Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin // J. Med. Chem. - 2001. - V.46. - №19. -P.4209-4212.
    10. Drent M.L. Larsson I., William-Olsson T. Orlistat a lipase inhibitor, in the

    139

    treatment of human obesity: a multiple dose study // Int. J. Obes. Relat. Metab. Disord. - 1995.-V.19. - №4. - P.221-226.

    1. Tsujita Т., Takaichi H., Takaku Т., Hiraki J. Inhibition of lipase activities by basic polysaccharide // J Lipid Res. - 2007. - V.48. - №.2. - P.358-365.
    2. Pernas M.A., Lopez C, Rua M.L. Influence of the conformational flexibility on the kinetics and dimerisation process of two Candida rugosa lipase isoenzymes //FEBS Letters. - 2001. - V.501. - №1. - P.87-91.
    3. Turner N.A., Needs E.C., Khan J.A. Analysis of conformational states of Candida rugosa lipase in solution: implications for mechanism of interfacial activation and separation of open and closed forms //Biotechnol. Bioeng. - 2001. -V.72.-№l.-P.108-118.
    4. Pereira E.B., Castro H.F., De Moraes F.F. Kinetic studies of lipase from Candida rugosa: a comparative study between free and immobilized enzyme onto porous chitosan beads // Appl. Biochem. Biotechnol. - 2001. - V.93. - №3. -P.739-752.
    5. Komura H., Kawase A., Iwaki M. Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol. // J. Pharm. Sci. - 2005. -V.94.-№12.-P.2656-2666.
    6. Grochulski P., Li Y., Schrag I. Two conformational states of Candida rugosa lipase // Protein Science. -1994. - V.3. - №1. - P.82-91.
    7. Rossner S., Sjostrom L., Noack R. Weight loss, weight maintenance, and improved cardiovascular risk factors after 2 years treatment with orlistat for obesity // Obesity Reseach. - 2000. - V. - 8. - № 1. - P.49-61.
    8. Pace D., Blother S., Guerciolini R. Short-term orlistat treatment does not affect mineral balance and bone turnover in obese men // J. Nutr. - 2001. - V.131. -№6.-P.1694-1699.

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    ч^

    ПРИЛОЖЕНИЕ

    141

    У

    Приложение 1


    ДАЮ

    «Биопрогресс» сор А.И. Албулов

    23 марта 2007 года

    АКТ

    О наработке водорастворимого хитозана для испытаний в медицине, пищевой промышленности и сельском хозяйстве.

    Нами, заведующим лаборатории инженерии ферментов Центра «Биоинженерия» РАН, д.х.н. В.П. Варламовым, аспирантом Е.С. Останиной, главным технологом ЗАО «Биопрогресс», к.б.н. М.А. Фроловой в Центре «Биоинженерия» Российской Академии Наук разработана технология получения водорастворимого хитозана из кутикулы восковой моли. Данная технология была апробирована в условиях производства на ЗАО «Биопрогресс» и проведена наработка водорастворимого хитозана в количестве 1 (одного) кг.

    Полученный    продукт    изготовлен    для    испытаний    в    медицине, ветеринарии, пищевой промышленности и сельском хозяйстве.


    В.П. Варламов Е.С. Останина М.А. Фролова

     

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    Источник: ОСТАНИНА ЕКАТЕРИНА СЕРГЕЕВНА. ТЕХНОЛОГИЯ ПЕРЕРАБОТКИ ВОСКОВОЙ МОЛИ, ИЗУЧЕНИЕ ПРОТИВОТУБЕРКУЛЕЗНЫХ СВОЙСТВ ХИТОЗАНА И ВЗАИМОДЕЙСТВИЯ С ЛИПОЛИТИЧЕСКИМИ ФЕРМЕНТАМИ. Диссертация на соискание учёной степени кандидата биологических наук. Щёлково-2007. 2007

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